Change search
ReferencesLink to record
Permanent link

Direct link
Induction of a parafacial rhythm generator by rhombomere 3 in the chick embryo.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
Show others and affiliations
2004 (English)In: Journal of Neuroscience, ISSN 0270-6474, E-ISSN 1529-2401, Vol. 24, no 42, 9383-9390 p.Article in journal (Refereed) Published
Abstract [en]

Observations of knock-out mice suggest that breathing at birth requires correct development of a specific hindbrain territory corresponding to rhombomeres (r) 3 and 4. Focusing on this territory, we examined the development of a neuronal rhythm generator in the chick embryo. We show that rhythmic activity in r4 is inducible after developmental stage 10 through interaction with r3. Although the nature of this interaction remains obscure, we find that the expression of Krox20, a segmentation gene responsible for specifying r3 and r5, is sufficient to endow other rhombomeres with the capacity to induce rhythmic activity in r4. Induction is robust, because it can be reproduced with r2 and r6 instead of r4 and with any hindbrain territory that normally expresses Krox20 (r3, r5) or can be forced to do so (r1, r4). Interestingly, the interaction between r4 and r3/r5 that results in rhythm production can only take place through the anterior border of r4, revealing a heretofore unsuspected polarity in individual rhombomeres. The r4 rhythm generator appears to be homologous to a murine respiratory parafacial neuronal system developing in r4 under the control of Krox20 and Hoxa1. These results identify a late role for Krox20 at the onset of neurogenesis.

Place, publisher, year, edition, pages
2004. Vol. 24, no 42, 9383-9390 p.
National Category
Developmental Biology
URN: urn:nbn:se:umu:diva-84174DOI: 10.1523/JNEUROSCI.2408-04.2004PubMedID: 15496674OAI: diva2:679871
Available from: 2013-12-16 Created: 2013-12-16 Last updated: 2014-02-17Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Coutinho, Ana PBorday, CarolineGilthorpe, JonathanJungbluth, StefanChampagnat, JeanLumsden, AndrewFortin, Gilles
By organisation
Clinical Neuroscience
In the same journal
Journal of Neuroscience
Developmental Biology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 23 hits
ReferencesLink to record
Permanent link

Direct link