Future of Brain Stimulation: New Targets, New Indications, New Technology
2013 (English)In: Movement Disorders, ISSN 0885-3185, E-ISSN 1531-8257, Vol. 28, no 13, 1784-1792 p.Article, review/survey (Refereed) Published
In the last quarter of a century, DBS has become an established neurosurgical treatment for Parkinson's disease (PD), dystonia, and tremors. Improved understanding of brain circuitries and their involvement in various neurological and psychiatric illnesses, coupled with the safety of DBS and its exquisite role as a tool for ethical study of the human brain, have unlocked new opportunities for this technology, both for future therapies and in research. Serendipitous discoveries and advances in structural and functional imaging are providing abundant new brain targets for an ever-increasing number of pathologies, leading to investigations of DBS in diverse neurological, psychiatric, behavioral, and cognitive conditions. Trials and proof of concept studies of DBS are underway in pain, epilepsy, tinnitus, OCD, depression, and Gilles de la Tourette syndrome, as well as in eating disorders, addiction, cognitive decline, consciousness, and autonomic states. In parallel, ongoing technological development will provide pulse generators with longer battery longevity, segmental electrode designs allowing a current steering, and the possibility to deliver on-demand stimulation based on closed-loop concepts. The future of brain stimulation is certainly promising, especially for movement disordersthat will remain the main indication for DBS for the foreseeable futureand probably for some psychiatric disorders. However, brain stimulation as a technique may be at risk of gliding down a slippery slope: Some reports indicate a disturbing trend with suggestions that future DBS may be proposed for enhancement of memory in healthy people, or as a tool for treatment of antisocial behavior and for improving morality. (c) 2013 International Parkinson and Movement Disorder Society
Place, publisher, year, edition, pages
Wiley-Blackwell, 2013. Vol. 28, no 13, 1784-1792 p.
deep brain stimulation, future, Parkinson's disease, movement disorders, psychiatry, behavior, cognition, addiction, eating disorders, ethics
IdentifiersURN: urn:nbn:se:umu:diva-84127DOI: 10.1002/mds.25665ISI: 000326859600006OAI: oai:DiVA.org:umu-84127DiVA: diva2:680261