Word-level intelligibility after caudal zona incerta stimulation for Parkinson’s disease
2014 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 130, no 1, 27-33 p.Article in journal (Refereed) Published
Objectives – To investigate the effect of caudal zona incerta-deep brain stimulation (cZi-DBS) on word-level speech intelligibility in patients with Parkinson’s disease, under both an optimal listening condition and a simulated more naturalistic listening condition.
Materials and methods – Spoken single words were extracted from read samples collected from 10 bilaterally implanted patients with PD pre- and post-cZi-DBS. Intelligibility was assessed through a transcription task performed by 32 naive listeners under two listening conditions: (i) with low-amplitude conversational speech added as background and (ii) with no added background noise. The listeners′ responses were scored in terms of agreement with the intended words.
Results – Post-operatively, the total intelligibility score was significantly lower when cZi stimulation was switched on compared with off, for both listening conditions (with and without added background noise). Intelligibility was also significantly lower on stimulation compared with preoperative recordings, but only when assessed in the listening condition without background noise. The listening condition with added background noise resulted in significantly lower intelligibility scores compared with the no added noise condition for all stimulation conditions.
Conclusions – The results of this study indicate that cZi-DBS in patients with PD can be detrimental to word-level speech intelligibility.
Place, publisher, year, edition, pages
Wiley-Blackwell, 2014. Vol. 130, no 1, 27-33 p.
caudal zona incerta, deep brain stimulation, Parkinson's disease, speech intelligibility
Other Medical Sciences not elsewhere specified
Research subject Neurology; Linguistics; Neurosurgery
IdentifiersURN: urn:nbn:se:umu:diva-84232DOI: 10.1111/ane.12210ISI: 000337633400004OAI: oai:DiVA.org:umu-84232DiVA: diva2:680948
ProjectsEn kontrastiv och longitudinell studie gällande effekten av djup hjärnstimulering på Parkinsons-patienters artikulatoriska förmåga.Intonation and rhythm in speech of patients with Parkinson ́s disease
FunderSwedish Research Council, 2009-946Swedish Research Council, 2011- 2294