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DNA-level diversity and relatedness of Helicobacter pylori strains in shantytown families in Peru and transmission in a developing-country setting.
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
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2008 (English)In: Journal of Clinical Microbiology, ISSN 0095-1137, E-ISSN 1098-660X, Vol. 46, no 12, 3912-3918 p.Article in journal (Refereed) Published
Abstract [en]

The efficiency of transmission of a pathogen within families compared with that between unrelated persons can affect both the strategies needed to control or eradicate infection and how the pathogen evolves. In industrialized countries, most cases of transmission of the gastric pathogen Helicobacter pylori seems to be from mother to child. An alternative model, potentially applicable among the very poor in developing countries, where infection is more common and the sanitary infrastructure is often deficient, invokes frequent transmission among unrelated persons, often via environmental sources. In the present study, we compared the genotypes of H. pylori from members of shantytown households in Peru to better understand the transmission of H. pylori in developing-country settings. H. pylori cultures and/or DNAs were obtained with informed consent by the string test (a minimally invasive alternative to endoscopy) from at least one child and one parent from each of 62 families. The random amplified polymorphic DNA fingerprints of 57 of 81 (70%) child-mother strain pairs did not match, nor did the diagnostic gene sequences (>1% DNA sequence difference), independent of the child's age (range, 1 to 39 years). Most strains from siblings or other paired family members were also unrelated. These results suggest that H. pylori infections are often community acquired in the society studied. Transmission between unrelated persons should facilitate the formation of novel recombinant genotypes by interstrain DNA transfer and selection for genotypes that are well suited for individual hosts. It also implies that the effective prevention of H. pylori infection and associated gastroduodenal disease will require anti-H. pylori measures to be applied communitywide.

Place, publisher, year, edition, pages
2008. Vol. 46, no 12, 3912-3918 p.
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:umu:diva-84596DOI: 10.1128/JCM.01453-08PubMedID: 18842944OAI: oai:DiVA.org:umu-84596DiVA: diva2:685880
Available from: 2014-01-09 Created: 2014-01-09 Last updated: 2017-12-06Bibliographically approved
In thesis
1. Diversity and adaptation in the adherence properties of Helicobacter pylori
Open this publication in new window or tab >>Diversity and adaptation in the adherence properties of Helicobacter pylori
2014 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Umeå: Umeå universitet, 2014. 39 p.
Series
Umeå University medical dissertations, ISSN 0346-6612 ; 1602
Keyword
Helicobacter pylori, transmission, phylogeny, native populations, bacterial adherence, BabA adhesin, receptor specificity, functional polymorphism, genetic diversity, adaptation
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
urn:nbn:se:umu:diva-84597 (URN)978-91-7459-734-9 (ISBN)
Public defence
2014-01-24, Naturvetarhuset, N300, Umeå universitet, Umeå, 10:00 (English)
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Available from: 2014-01-10 Created: 2014-01-10 Last updated: 2014-12-17Bibliographically approved

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Mendez, Melissa

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