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Helicobacter pylori from Peruvian amerindians: traces of human migrations in strains from remote Amazon, and genome sequence of an Amerind strain
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
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2010 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 5, no 11, e15076- p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The gastric pathogen Helicobacter pylori is extraordinary in its genetic diversity, the differences between strains from well-separated human populations, and the range of diseases that infection promotes.

PRINCIPAL FINDINGS: Housekeeping gene sequences from H. pylori from residents of an Amerindian village in the Peruvian Amazon, Shimaa, were related to, but not intermingled with, those from Asia. This suggests descent of Shimaa strains from H. pylori that had infected the people who migrated from Asia into The Americas some 15,000+ years ago. In contrast, European type sequences predominated in strains from Amerindian Lima shantytown residents, but with some 12% Amerindian or East Asian-like admixture, which indicates displacement of ancestral purely Amerindian strains by those of hybrid or European ancestry. The genome of one Shimaa village strain, Shi470, was sequenced completely. Its SNP pattern was more Asian- than European-like genome-wide, indicating a purely Amerind ancestry. Among its unusual features were two cagA virulence genes, each distinct from those known from elsewhere; and a novel allele of gene hp0519, whose encoded protein is postulated to interact with host tissue. More generally, however, the Shi470 genome is similar in gene content and organization to those of strains from industrialized countries.

CONCLUSIONS: Our data indicate that Shimaa village H. pylori descend from Asian strains brought to The Americas many millennia ago; and that Amerind strains are less fit than, and were substantially displaced by, hybrid or European strains in less isolated communities. Genome comparisons of H. pylori from Amerindian and other communities should help elucidate evolutionary forces that have shaped pathogen populations in The Americas and worldwide.

Place, publisher, year, edition, pages
2010. Vol. 5, no 11, e15076- p.
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:umu:diva-83678DOI: 10.1371/journal.pone.0015076PubMedID: 21124785OAI: oai:DiVA.org:umu-83678DiVA: diva2:685881
Available from: 2014-01-09 Created: 2013-12-03 Last updated: 2017-12-06Bibliographically approved
In thesis
1. Diversity and adaptation in the adherence properties of Helicobacter pylori
Open this publication in new window or tab >>Diversity and adaptation in the adherence properties of Helicobacter pylori
2014 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Umeå: Umeå universitet, 2014. 39 p.
Series
Umeå University medical dissertations, ISSN 0346-6612 ; 1602
Keyword
Helicobacter pylori, transmission, phylogeny, native populations, bacterial adherence, BabA adhesin, receptor specificity, functional polymorphism, genetic diversity, adaptation
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
urn:nbn:se:umu:diva-84597 (URN)978-91-7459-734-9 (ISBN)
Public defence
2014-01-24, Naturvetarhuset, N300, Umeå universitet, Umeå, 10:00 (English)
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Available from: 2014-01-10 Created: 2014-01-10 Last updated: 2014-12-17Bibliographically approved

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