umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The Resveratrol Tetramer (-)-Hopeaphenol Inhibits Type III Secretion in the Gram-Negative Pathogens Yersinia pseudotuberculosis and Pseudomonas aeruginosa
Umeå University, Faculty of Science and Technology, Department of Chemistry. Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). (Mikael Elofsson)
Creative Antibiotics Sweden AB, Umeå, Sweden .
Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). Umeå University, Faculty of Medicine, Department of Clinical Microbiology.
Eskitis Institute, Griffith University, Brisbane, Australia.
Show others and affiliations
2013 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 8, no 12, e81969- p.Article in journal (Refereed) Published
Abstract [en]

Society faces huge challenges, as a large number of bacteria have developed resistance towards many or all of the antibiotics currently available. Novel strategies that can help solve this problem are urgently needed. One such strategy is to target bacterial virulence, the ability to cause disease e.g., by inhibition of type III secretion systems (T3SSs) utilized by many clinically relevant gram-negative pathogens. Many of the antibiotics used today originate from natural sources. In contrast, most virulence-blocking compounds towards the T3SS identified so far are small organic molecules. A recent high-throughput screening of a prefractionated natural product library identified the resveratrol tetramer (-)-hopeaphenol as an inhibitor of the T3SS in Yersinia pseudotuberculosis. In this study we have investigated the virulence blocking properties of (-)-hopeaphenol in three different gram-negative bacteria. (-)- Hopeaphenol was found to have micromolar activity towards the T3SSs in Yersinia pseudotuberculosis and Pseudomonas aeruginosa in cell-based infection models. In addition (-)-hopeaphenol reduced cell entry and subsequent intracellular growth of Chlamydia trachomatis.

Place, publisher, year, edition, pages
PloS ONE , 2013. Vol. 8, no 12, e81969- p.
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:umu:diva-84598DOI: 10.1371/journal.pone.0081969OAI: oai:DiVA.org:umu-84598DiVA: diva2:685921
Funder
Swedish Research Council
Available from: 2014-01-10 Created: 2014-01-10 Last updated: 2017-12-06Bibliographically approved

Open Access in DiVA

Plos one CEZ(1226 kB)245 downloads
File information
File name FULLTEXT02.pdfFile size 1226 kBChecksum SHA-512
c71979acf3d53bbf61d98a26fcd38d8b6d571c499001d34fbffe8fff287fcb2c319f788d548b8a765355a0c31152b56181a1f2a9472da947a4f73aa8c0419a2d
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Zetterström, Caroline E.Salin, OlliElofsson, Mikael
By organisation
Department of ChemistryUmeå Centre for Microbial Research (UCMR)Department of Clinical Microbiology
In the same journal
PLoS ONE
Chemical Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 245 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 166 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf