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A new world of Polycombs: unexpected partnerships and emerging functions
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
2013 (English)In: Nature reviews genetics, ISSN 1471-0056, E-ISSN 1471-0064, Vol. 14, no 12, 853-864 p.Article, review/survey (Refereed) Published
Abstract [en]

Polycomb group (PcG) proteins are epigenetic repressors that are essential for the transcriptional control of cell differentiation and development. PcG-mediated repression is associated with specific post-translational histone modifications and is thought to involve both biochemical and physical modulation of chromatin structure. Recent advances show that PcG complexes comprise a multiplicity of variants and are far more biochemically diverse than previously thought. The importance of these new PcG complexes for normal development and disease, their targeting mechanisms and their shifting roles in the course of differentiation are now the subject of investigation and the focus of this Review.

Place, publisher, year, edition, pages
Nature Publishing Group, 2013. Vol. 14, no 12, 853-864 p.
National Category
Medical Genetics
Identifiers
URN: urn:nbn:se:umu:diva-84516DOI: 10.1038/nrg3603ISI: 000327442800010OAI: oai:DiVA.org:umu-84516DiVA: diva2:687422
Funder
Swedish Research CouncilCarl Tryggers foundation
Available from: 2014-01-14 Created: 2014-01-08 Last updated: 2017-12-06Bibliographically approved

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Schwartz, Yuri B.

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