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The many flavors of tumor-associated B cells
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Urology and Andrology.
2013 (English)In: Oncoimmunology, ISSN 2162-4011 (print), 2162-402X (online), Vol. 2, no 8, e25237- p.Article in journal (Refereed) Published
Abstract [en]

Little is known on the role of distinct B-cell subtypes in human malignancies. We have recently performed a multiplex characterization of B cells in patient-derived tumor-associated tissues, documenting the activation and antigen-driven differentiation of B cells in metastatic lymph nodes and neoplastic lesions. Here we discuss the role of B lymphocytes as antigen-presenting cells and catalysts of T cell-based immunotherapies in view of these findings.

Place, publisher, year, edition, pages
Landes Bioscience , 2013. Vol. 2, no 8, e25237- p.
Keyword [en]
adoptive immunotherapy, antigen-presenting cell, B-cell subtypes, clonal expansion, tumor-draining lymph nodes
National Category
Clinical Medicine Cancer and Oncology Immunology in the medical area
Identifiers
URN: urn:nbn:se:umu:diva-84887DOI: 10.4161/onci.25237ISI: 000330424100024PubMedID: 24167763OAI: oai:DiVA.org:umu-84887DiVA: diva2:689870
Available from: 2014-01-22 Created: 2014-01-21 Last updated: 2014-03-10Bibliographically approved

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Sherif, Amir

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