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Temporal shifts in cardiovascular risk factor distribution
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health. Umeå University, Faculty of Social Sciences, Centre for Population Studies (CPS). Ageing and Living Conditions Programme. (Arcum)ORCID iD: 0000-0003-2475-7131
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Family Medicine.
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2014 (English)In: American Journal of Preventive Medicine, ISSN 0749-3797, E-ISSN 1873-2607, Vol. 46, no 2, 112-121 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Complementary strategies to shift risk factor population distributions and target high-risk individuals are required to reduce the burden of type 2 diabetes and cardiovascular disease (CVD).

PURPOSE: To examine secular changes in glucose and CVD risk factors over 20 years during an individual and population-based CVD prevention program in Västerbotten County, Sweden.

METHODS: Population-based health promotion intervention was conducted and annual invitation for individuals turning 40, 50, and 60 years to attend a health assessment, including an oral glucose tolerance test, biochemical measures, and a questionnaire. Data were collected between 1991 and 2010, analyzed in 2012 and available for 120,929 individuals. Linear regression modeling examined age-adjusted differences in CVD risk factor means over time. Data were direct-age-standardized to compare disease prevalence.

RESULTS: Between 1991-1995 and 2006-2010, mean age-adjusted cholesterol (men=-0.53, 95% CI=-0.55, -0.50 mmol/L; women=-0.48, 95% CI=-0.50, -0.45 mmol/L) and systolic blood pressure declined (men=-3.06, 95% CI=-3.43, -2.70 mm Hg; women=-5.27, 95% CI=-5.64, -4.90 mm Hg), with corresponding decreases in the age-standardized prevalence of hypertension and hyperlipidemia. Mean age-adjusted 2-hour plasma glucose (men=0.19, 95% CI=0.15, 0.23 mmol/L; women=0.08, 95% CI=0.04, 0.11 mmol/L) and BMI increased (men=1.12, 95% CI=1.04, 1.21; women=0.65, 95% CI=0.55, 0.75), with increases in the age-standardized prevalence of diabetes and obesity.

CONCLUSIONS: These data demonstrate the potential of combined individual- and population-based approaches to CVD risk factor control and highlight the need for additional strategies addressing hyperglycemia and obesity.

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 46, no 2, 112-121 p.
National Category
Public Health, Global Health, Social Medicine and Epidemiology Endocrinology and Diabetes Cardiac and Cardiovascular Systems
URN: urn:nbn:se:umu:diva-84974DOI: 10.1016/j.amepre.2013.10.011PubMedID: 24439344OAI: diva2:690578
Forte, Swedish Research Council for Health, Working Life and Welfare, FAS 2006_1512Swedish Research Council, 2006-21576-36119-666NIH (National Institute of Health), RP-PG-0606-1259
Available from: 2014-01-24 Created: 2014-01-24 Last updated: 2016-05-23Bibliographically approved

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Norberg, MargaretaWennberg, PatrikLindahl, BerntRolandsson, OlovWeinehall, Lars
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Public Health, Global Health, Social Medicine and EpidemiologyEndocrinology and DiabetesCardiac and Cardiovascular Systems

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