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Complications of vagal nerve stimulation for drug-resistant epilepsy: A single center longitudinal study of 143 patients
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
2013 (English)In: Seizure, ISSN 1059-1311, Vol. 22, no 10, 827-833 p.Article in journal (Refereed) Published
Abstract [en]

Purpose: To longitudinally study surgical and hardware complications to vagal nerve stimulation (VNS) treatment in patients with drug-resistant epilepsy. Methods: In a longitudinal retrospective study, we analyzed surgical and hardware complications in 143 patients (81 men and 62 women) who between 1994 and 2010 underwent implantation of a VHS-device for drug-resistant epilepsy. The mean follow-up time was 62 +/- 46 months and the total number of patient years 738. Results: 251 procedures were performed on 143 patients. 16.8% of the patients were afflicted by complications related to surgery and 16.8% suffered from hardware malfunctions. Surgical complications were: superficial infection in 3.5%, deep infection needing explantation in 3.5%, vocal cord palsy in 5.6%, which persisted in at least 0.7% for over one year, and other complications in 5.6%. Hardware-related complications were: lead fracture in 11.9% of patients, disconnection in 2.8%, spontaneous turn-off in 1.4% and stimulator malfunction in 1.4%. We noted a tendency to different survival times between the two most commonly used lead models as well as a tendency to increased infection rate with increasing number of stimulator replacements. Conclusion: In this series we report on surgical and hardware complications from our 16 years of experience with VNS treatment. Infection following insertion of the VNS device and vocal cord palsy due to damage to the vagus nerve are the most serious complications related to the surgery. Avoiding unnecessary reoperations in order to reduce the appearances of these complications are of great importance. It is therefore essential to minimize technical malfunctions that will lead to additional surgery. Further studies are needed to evaluate the possible superiority of the modified leads.

Place, publisher, year, edition, pages
Saunders Elsevier, 2013. Vol. 22, no 10, 827-833 p.
Keyword [en]
Vagal nerve stimulation, Complication, Epilepsy
National Category
URN: urn:nbn:se:umu:diva-85098DOI: 10.1016/j.seizure.2013.06.011ISI: 000327687300004OAI: diva2:691740
Available from: 2014-01-28 Created: 2014-01-28 Last updated: 2014-01-28Bibliographically approved

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Kahlow, HannesOlivecrona, Magnus
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