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Health effects of diesel exhaust emissions
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Pulmonary Medicine. Dept of Respiratory Medicine and Allergy, University Hospital, Umeå.
Dept of Respiratory Medicine and Allergy, University Hospital, Umeå and Respiratory Cell and Molecular Biology Research Division, Southampton General Hospital, Tremona Road, Southampton, UK.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Pulmonary Medicine. Dept of Respiratory Medicine and Allergy, University Hospital, Umeå.
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2001 (English)In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 17, no 4, 733-746 p.Article in journal (Refereed) Published
Abstract [en]

Epidemiological studies have demonstrated an association between different levels of air pollution and various health outcomes including mortality, exacerbation of asthma, chronic bronchitis, respiratory tract infections, ischaemic heart disease and stroke. Of the motor vehicle generated air pollutants, diesel exhaust particles account for a highly significant percentage of the particles emitted in many towns and cities. This review is therefore focused on the health effects of diesel exhaust, and especially the particular matter components. Acute effects of diesel exhaust exposure include irritation of the nose and eyes, lung function changes, respiratory changes, headache, fatigue and nausea. Chronic exposures are associated with cough, sputum production and lung function decrements. In addition to symptoms, exposure studies in healthy humans have documented a number of profound inflammatory changes in the airways, notably, before changes in pulmonary function can be detected. It is likely that such effects may be even more detrimental in asthmatics and other subjects with compromised pulmonary function. There are also observations supporting the hypothesis that diesel exhaust is one important factor contributing to the allergy pandemic. For example, in many experimental systems, diesel exhaust particles can be shown to act as adjuvants to allergen and hence increase the sensitization response. Much of the research on adverse effects of diesel exhaust, both in vivo and in vitro, has however been conducted in animals. Questions remain concerning the relevance of exposure levels and whether findings in such models can be extrapolated into humans. It is therefore imperative to further assess acute and chronic effects of diesel exhaust in mechanistic studies with careful consideration of exposure levels. Whenever possible and ethically justified, studies should be carried out in humans.

Place, publisher, year, edition, pages
2001. Vol. 17, no 4, 733-746 p.
Keyword [en]
air pollution, allergy incidence, animal studies, asthma exacerbation, diesel, human exposure
National Category
Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:umu:diva-85676DOI: 10.1183/09031936.01.17407330ISI: 000169050400026PubMedID: 11401072OAI: oai:DiVA.org:umu-85676DiVA: diva2:695063
Funder
Swedish Heart Lung FoundationSwedish Research Council, No 9071
Available from: 2014-02-10 Created: 2014-02-10 Last updated: 2017-12-06Bibliographically approved

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