Determination of the biodistribution and dosimetry of I-123-FP-CIT in male patients with suspected Parkinsonism or Lewy body dementia using planar and combined planar and SPECT/CT imaging
2013 (English)In: Applied Radiation and Isotopes, ISSN 0969-8043, E-ISSN 1872-9800, Vol. 82, 300-307 p.Article in journal (Refereed) Published
In this study, I-123-FP-CIT biodistribution and dosimetry was determined in 10 adult male patients using planar gamma camera imaging alone or in combination with single photon emission computed tomography /X-ray computed tomography (SPECT/CT) imaging. Dosimetric assessment using planar plus SPECT/CT imaging resulted in significantly different estimates of organ-absorbed doses compared to estimates based on planar imaging alone. We conclude that the use of complementary SPECT/CT measurements in biodistribution studies is valuable for determining the organ doses more accurately.
Place, publisher, year, edition, pages
Elsevier, 2013. Vol. 82, 300-307 p.
Biokinetics, Dosimetry, I-123-FP-CIT, Lewy body dementia, Parkinson's disease
Radiology, Nuclear Medicine and Medical Imaging
IdentifiersURN: urn:nbn:se:umu:diva-85635DOI: 10.1016/j.apradiso.2013.09.006ISI: 000328804000046OAI: oai:DiVA.org:umu-85635DiVA: diva2:695073
FunderEU, FP7, Seventh Framework Programme, FP7-212100Swedish Radiation Safety Authority, SSM 2009/3400, 1586-01