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Determination of the biodistribution and dosimetry of I-123-FP-CIT in male patients with suspected Parkinsonism or Lewy body dementia using planar and combined planar and SPECT/CT imaging
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.
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2013 (English)In: Applied Radiation and Isotopes, ISSN 0969-8043, E-ISSN 1872-9800, Vol. 82, 300-307 p.Article in journal (Refereed) Published
Abstract [en]

In this study, I-123-FP-CIT biodistribution and dosimetry was determined in 10 adult male patients using planar gamma camera imaging alone or in combination with single photon emission computed tomography /X-ray computed tomography (SPECT/CT) imaging. Dosimetric assessment using planar plus SPECT/CT imaging resulted in significantly different estimates of organ-absorbed doses compared to estimates based on planar imaging alone. We conclude that the use of complementary SPECT/CT measurements in biodistribution studies is valuable for determining the organ doses more accurately.

Place, publisher, year, edition, pages
Elsevier, 2013. Vol. 82, 300-307 p.
Keyword [en]
Biokinetics, Dosimetry, I-123-FP-CIT, Lewy body dementia, Parkinson's disease
National Category
Radiology, Nuclear Medicine and Medical Imaging
URN: urn:nbn:se:umu:diva-85635DOI: 10.1016/j.apradiso.2013.09.006ISI: 000328804000046OAI: diva2:695073
EU, FP7, Seventh Framework Programme, FP7-212100Swedish Radiation Safety Authority, SSM 2009/3400, 1586-01
Available from: 2014-02-10 Created: 2014-02-07 Last updated: 2014-02-10Bibliographically approved

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Lizana, Helena
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