Change search
ReferencesLink to record
Permanent link

Direct link
High expression of p63 is correlated to poor prognosis in squamous cell carcinoma of the tongue
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Otorhinolaryngology.
Show others and affiliations
2014 (English)In: Journal of Oral Pathology & Medicine, ISSN 0904-2512, E-ISSN 1600-0714, Vol. 43, no 1, 14-19 p.Article in journal (Refereed) Published
Abstract [en]

Backgroundp63 proteins are important in formation of the oral mucosa. Normal oral mucosa shows a balance between the six protein isoforms, whereas an imbalance between them is seen in squamous cell carcinomas (SCC). There is controversy over the clinical impact of p63 in SCC, which may relate to different expression in different areas. In addition, p63 isoforms can act as p53-like molecules (TAp63) or can inhibit p53 functions (Np63) and expression of these isoforms varies in different tumours. Here, we chose to concentrate on the most common intra-oral sub-site, SCC of the mobile tongue. MethodsTotal p63, Np63 and TAp63 were analysed separately using immunohistochemistry. The percentage of cells and intensity of expression of different isoforms of p63 was evaluated using a quick score method and correlated with clinical data in a group of 87 patients with tongue SCC. ResultsAll tumours expressed p63 in at least 60% of the cells when using two different antibodies detecting all 6 isoforms. p63 expression correlated significantly with 2-year survival (P=0.018), with fewer patients surviving 2years if their tumours expressed p63 with strong intensity in at least 80% of the cells (quick score 18). Looking at 5-year survival, this was even more emphasized. Np63 was expressed in all tumours, whereas expression of TAp63 was seen only in 59/87 patients, usually at very low levels. ConclusionsBased on the present data, we recommend using expression of p63 as an additional factor contributing prognostic information in analysis of SCC in the tongue.

Place, publisher, year, edition, pages
John Wiley & Sons, 2014. Vol. 43, no 1, 14-19 p.
Keyword [en]
p63, prognosis, tongue carcinoma
National Category
Dentistry Surgery
URN: urn:nbn:se:umu:diva-85784DOI: 10.1111/jop.12074ISI: 000329291500003OAI: diva2:696140
Swedish Cancer Society, 11 0651
Available from: 2014-02-13 Created: 2014-02-10 Last updated: 2014-02-13Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Loljung, LottaLaurell, GöranWahlgren, MagnusWilms, TorbenWidlöf, MikaelHansel, AnnaNylander, Karin
By organisation
In the same journal
Journal of Oral Pathology & Medicine

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 109 hits
ReferencesLink to record
Permanent link

Direct link