Air Pollution and Non-Malignant Respiratory Mortality in 16 Cohorts within the ESCAPE Project
2014 (English)In: American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, E-ISSN 1535-4970, Vol. 189, no 6, 684-696 p.Article in journal (Refereed) Published
Rationale: Prospective cohort studies have shown that chronic exposure to particulate matter and traffic related air pollution is associated with reduced survival. However, the effects on non-malignant respiratory mortality are less studied and those reported are less consistent.
Objectives: We have investigated the relationship of long-term exposure to air pollution and non-malignant respiratory mortality in 16 cohorts with individual level data within the multi center European Study of Cohorts for Air Pollution Effects (ESCAPE).
Methods: Data from 16 ongoing cohort studies from Europe were used. The total number of subjects was 307,553. There were 1,559 respiratory deaths during follow-up.
Measurements: Air pollution exposure was estimated by land use regression models at the baseline residential addresses of study participants and traffic-proximity variables were derived from geographical databases, following a standardized procedure within ESCAPE study. Cohort-specific hazard ratios obtained by Cox proportional hazard models from standardized individual cohort analyses were combined using meta-analyses. Main Results: We found no significant associations between air pollution exposure and non-malignant respiratory mortality. Most hazard ratios were slightly below unity, with the exception of the traffic-proximity indicators.
Conclusions: In this study of 16 cohorts there was no association between air pollution exposure and non malignant respiratory mortality.
Place, publisher, year, edition, pages
American Thoracic Society , 2014. Vol. 189, no 6, 684-696 p.
environmental exposure, public health, metaanalysis
Environmental Health and Occupational Health
IdentifiersURN: urn:nbn:se:umu:diva-86124DOI: 10.1164/rccm.201310-1777OCISI: 000333381100013PubMedID: 24521254OAI: oai:DiVA.org:umu-86124DiVA: diva2:697400