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Air Pollution and Non-Malignant Respiratory Mortality in 16 Cohorts within the ESCAPE Project
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2014 (Engelska)Ingår i: American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, E-ISSN 1535-4970, Vol. 189, nr 6, s. 684-696Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Rationale: Prospective cohort studies have shown that chronic exposure to particulate matter and traffic related air pollution is associated with reduced survival. However, the effects on non-malignant respiratory mortality are less studied and those reported are less consistent.

Objectives: We have investigated the relationship of long-term exposure to air pollution and non-malignant respiratory mortality in 16 cohorts with individual level data within the multi center European Study of Cohorts for Air Pollution Effects (ESCAPE).

Methods: Data from 16 ongoing cohort studies from Europe were used. The total number of subjects was 307,553. There were 1,559 respiratory deaths during follow-up.

Measurements: Air pollution exposure was estimated by land use regression models at the baseline residential addresses of study participants and traffic-proximity variables were derived from geographical databases, following a standardized procedure within ESCAPE study. Cohort-specific hazard ratios obtained by Cox proportional hazard models from standardized individual cohort analyses were combined using meta-analyses. Main Results: We found no significant associations between air pollution exposure and non-malignant respiratory mortality. Most hazard ratios were slightly below unity, with the exception of the traffic-proximity indicators.

Conclusions: In this study of 16 cohorts there was no association between air pollution exposure and non malignant respiratory mortality.

Ort, förlag, år, upplaga, sidor
American Thoracic Society , 2014. Vol. 189, nr 6, s. 684-696
Nyckelord [en]
environmental exposure, public health, metaanalysis
Nationell ämneskategori
Arbetsmedicin och miljömedicin
Identifikatorer
URN: urn:nbn:se:umu:diva-86124DOI: 10.1164/rccm.201310-1777OCISI: 000333381100013PubMedID: 24521254OAI: oai:DiVA.org:umu-86124DiVA, id: diva2:697400
Tillgänglig från: 2014-02-18 Skapad: 2014-02-18 Senast uppdaterad: 2018-06-08Bibliografiskt granskad

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Förlagets fulltextPubMedhttp://www.atsjournals.org/doi/abs/10.1164/rccm.201310-1777OC

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Oudin, AnnaForsberg, BertilModig, Lars

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