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Individual PAI-1 increase over nine years relates differently in men and women to changes in anthropometric, glycaemic, inflammatory and lipid markers.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine. (Skellefteå Research Unit)
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine. (Sunderby Reserach Unit)
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Clinical chemistry.
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(English)Manuscript (preprint) (Other academic)
Abstract [en]

Background: Levels of plasminogen activator inhibitor-1 (PAI-1) is known to correlate to factors related to the metabolic syndrome. We have previously shown that PAI-1 antigen increased by 75% in men and 95% in women over nine years.

Objective: The aim of this study was to explore relationships between intra-individual changes in PAI-1 and changes in anthropometric measurements, blood pressure, glycaemic, lipid and inflammatory markers, separately for men and women.

Method: In northern Sweden, 125 men and 116 women were examined first in 1990 and re-examined in 1999 during the morning hours. Changes over time (Δ) were calculated as the value at 1999 minus the value at 1990.

Results: In men, ΔPAI-1 was significantly correlated to ΔBMI (r =0.33), ΔCRP (r =0.25), Δtriglycerides (r =0.39), Δfasting plasma glucose (r =0.41) and Δ2-hour plasma glucose (r =0.29). In women, ΔPAI-1 was significantly correlated to ΔBMI (r =0.36), Δwaist circumference (r =0.38), Δhip circumference (r =0.27), ΔCRP (r =0.27) and Δtotal cholesterol (r =0.19). The multivariate linear regression analysis showed that ΔPAI-1 was significantly related to Δfasting plasma glucose and ΔCRP in men (R2 for the complete model was 0.31). In women, ΔPAI-1 was significantly related to Δwaist circumference (R2 for the complete model was 0.17).

Conclusion: We expected that changes in anthropometric, glycaemic, inflammatory and lipid markers would explain a large part of the observed PAI-1 increase. However, the multivariate analysis explained only 20% of the variation in ΔPAI-1 in women and 30% in men. Interestingly, the patterns of components correlating with the changes in PAI-1 differed between sexes.

Keyword [en]
fibrinolysis, plasminogen activator inhibitor 1, longitudinal studies, gender
National Category
Public Health, Global Health, Social Medicine and Epidemiology Hematology
Research subject
Epidemiology
Identifiers
URN: urn:nbn:se:umu:diva-86359OAI: oai:DiVA.org:umu-86359DiVA: diva2:698566
Available from: 2014-02-24 Created: 2014-02-24 Last updated: 2014-02-28Bibliographically approved
In thesis
1. Fibrinolytic factors in relation to anthropometry and incident type 2 diabetes.
Open this publication in new window or tab >>Fibrinolytic factors in relation to anthropometry and incident type 2 diabetes.
2014 (English)Doctoral thesis, comprehensive summary (Other academic)
Alternative title[sv]
Fibrinolysfaktorer i relation till antropometri och incident typ 2 diabetes.
Abstract [en]

Fibrinolytic imbalance is associated with cardiovascular disease and its risk factors. The longitudinal changes in the fibrinolytic factors tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1) and tPA/PAI-1 complex have been inadequately studied in the general population and in relation to incident type 2 diabetes mellitus (T2DM). The measurements, questionnaires and blood samples prospectively collected in the World Health Organisation-project MONItoring trends and determinants in CArdiovascular disease (MONICA) and in the Västerbotten Intervention Programme (VIP) enable such studies. The samples have been stored since 1985, at the Northern Sweden Medical Research Biobank. However, it is unknown how these factors are affected by long-term storage.

The aims of this thesis were to evaluate the effects of long-term storage on fibrinolytic factors, and to determine how these factors are related to incident T2DM, how these factors change over time and how these factors are related to changes in anthropometric measurements.

Storage time was shown to have a negligible impact on plasma antigen levels of fibrinolytic factors. After adjustments for traditional diabetic and cardiovascular risk markers the fibrinolytic factors tPA, PAI-1 and tPA/PAI-1 complex were associated with incident T2DM. PAI-1 was associated with incident T2DM in subjects with normal fasting and 2-hour plasma glucose levels. In MONICA-Västerbotten, tPA, PAI-1 and tPA/PAI-1 complex increased over 9 years in both men and women. PAI-1 appears to interact in a complex manner with anthropometric, inflammatory, glycaemic and lipidemic measurements, but the pattern of components correlating with the changes in PAI-1 differed markedly between the sexes.

In conclusion, PAI-1 is a potential risk marker of incident T2DM. PAI-1 increased markedly over nine years, but the pathophysiological background to these findings needs to be further investigated, separately for each sex.

Place, publisher, year, edition, pages
Umeå: Umeå Universitet, 2014. 81 p.
Series
Umeå University medical dissertations, ISSN 0346-6612 ; 1626
National Category
Endocrinology and Diabetes Cardiac and Cardiovascular Systems Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public health; Medicine, cardiovascular disease
Identifiers
urn:nbn:se:umu:diva-86360 (URN)978-91-7459-796-7 (ISBN)
Public defence
2014-03-21, Forumsalen, Campus, Skellefteå, 13:00 (Swedish)
Opponent
Supervisors
Available from: 2014-02-28 Created: 2014-02-24 Last updated: 2014-03-17Bibliographically approved

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Hernestål-Boman, JennyJansson, Jan-HåkanEliasson, MatsNilsson, Torbjörn KJohansson, Lars
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