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Expression of LRIG1 is associated with good prognosis and human papillomavirus status in oropharyngeal cancer
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
Department of Oncology-Pathology, Karolinska Institute, SE-171 76, Stockholm, Sweden.
Department of Pathology and Clinical Cytology, Central Hospital Falun, SE-791 29, Falun, Sweden.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
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2014 (English)In: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 110, 1793-1800 p.Article in journal (Refereed) Published
Abstract [en]

Background:The incidence of human papillomavirus (HPV)-associated oropharyngeal cancer has increased rapidly during the past decades. HPV is typically associated with a favourable outcome; however, a need exists for new and more effective prognostic and predictive markers for this disease. Leucine-rich repeats and immunoglobulin-like domains (LRIG)-1 is a tumour suppressor protein that belongs to the LRIG family. LRIG1 expression has prognostic significance in various human cancers, including cervical cancer, where HPV is a key aetiological agent.Methods:The prognostic value of LRIG1 and LRIG2 immunoreactivity was investigated in tumour specimens from a Swedish cohort of patients with tonsillar and base of tongue oropharyngeal cancers, including 278 patients.Results:LRIG1 immunoreactivity correlated with disease-free survival and overall survival in univariate and multivariate analyses. Notably, patients with HPV-positive tumours with high LRIG1 staining intensity or a high percentage of LRIG1-positive cells showed a very good prognosis. Furthermore, LRIG1 expression correlated with HPV status, whereas LRIG2 expression inversely correlated with HPV status.Conclusions:Taken together, the results suggest that LRIG1 immunoreactivity could be a clinically important prognostic marker in HPV-associated oropharyngeal cancer.

Place, publisher, year, edition, pages
Nature Publishing Group, 2014. Vol. 110, 1793-1800 p.
Keyword [en]
LRIG1, CD44, HPV, p16
National Category
Cancer and Oncology
Research subject
URN: urn:nbn:se:umu:diva-86392DOI: 10.1038/bjc.2014.87PubMedID: 24548859OAI: diva2:698754
Available from: 2014-02-25 Created: 2014-02-25 Last updated: 2014-05-20Bibliographically approved

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Lindquist, DavidHenriksson, RogerHedman, Håkan
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