Signal regulatory protein alpha is present in several neutrophil granule populations and is rapidly mobilized to the cell surface to negatively fine-tune neutrophil accumulation in inflammation
2014 (English)In: Journal of Innate Immunity, ISSN 1662-811X, Vol. 6, no 4, 553-560 p.Article in journal (Refereed) Published
Signal regulatory protein alpha (SIRPα) is a cell surface glycoprotein with inhibitory functions, which may regulate neutrophil transmigration. SIRPα is mobilized to the neutrophil surface from specific granules, gelatinase granules, and secretory vesicles following inflammatory activation in vitro and in vivo. The lack of SIRPα signaling and the ability to upregulate SIRPα to the cell surface promote neutrophil accumulation during inflammation in vivo.
Place, publisher, year, edition, pages
2014. Vol. 6, no 4, 553-560 p.
Neutrophils, Inflammation, Signal regulatory protein alpha, Chemotactic factor, Skin window, Exudate
Other Basic Medicine
IdentifiersURN: urn:nbn:se:umu:diva-86668DOI: 10.1159/000357820ISI: 000337655900013PubMedID: 24516072OAI: oai:DiVA.org:umu-86668DiVA: diva2:700263