Genome-wide association study identifies multiple loci associated with bladder cancer risk
2014 (English)In: Human Molecular Genetics, ISSN 0964-6906, E-ISSN 1460-2083, Vol. 23, no 5, 1387-1398 p.Article in journal (Refereed) Published
andidate gene and genome-wide association studies (GWAS) have identified 11 independent susceptibility loci associated with bladder cancer risk. To discover additional risk variants, we conducted a new GWAS of 2422 bladder cancer cases and 5751 controls, followed by a meta-analysis with two independently published bladder cancer GWAS, resulting in a combined analysis of 6911 cases and 11 814 controls of European descent. TaqMan genotyping of 13 promising single nucleotide polymorphisms with P < 1 × 10−5 was pursued in a follow-up set of 801 cases and 1307 controls. Two new loci achieved genome-wide statistical significance: rs10936599 on 3q26.2 (P = 4.53 × 10−9) and rs907611 on 11p15.5 (P = 4.11 × 10−8). Two notable loci were also identified that approached genome-wide statistical significance: rs6104690 on 20p12.2 (P = 7.13 × 10−7) and rs4510656 on 6p22.3 (P = 6.98 × 10−7); these require further studies for confirmation. In conclusion, our study has identified new susceptibility alleles for bladder cancer risk that require fine-mapping and laboratory investigation, which could further understanding into the biological underpinnings of bladder carcinogenesis.
Place, publisher, year, edition, pages
Oxford University Press, 2014. Vol. 23, no 5, 1387-1398 p.
Medical Genetics Cancer and Oncology Cell and Molecular Biology
IdentifiersURN: urn:nbn:se:umu:diva-87402DOI: 10.1093/hmg/ddt519ISI: 000331815000022PubMedID: 24163127OAI: oai:DiVA.org:umu-87402DiVA: diva2:709546