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Diabetes induction in C57BL/6 mice reconstituted with lymphocytes of nonobese diabetic C57BL/6 mouse embryo aggregation chimeras
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). INSERM U429, Necker Hospital, Paris, France. (Department for Cell and Molecular Biology, University of Umeå, Umeå, Sweden)
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). (Department for Cell and Molecular Biology, University of Umeå, Umeå, Sweden)
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). (Department of Cell and Molecular Biology. University of Umeå)
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). (Department of Cell and Molecular Biology. University of Umeå)
1998 (English)In: Scandinavian Journal of Immunology, ISSN 0300-9475, E-ISSN 1365-3083, Vol. 48, no 6, 571-576 p.Article in journal (Refereed) Published
Abstract [en]

To determine whether the genetic background of the insulin-producing beta cells of the pancreas contributes to autoimmune diabetes susceptibility, we have used a model of the disease based on transferring spleen cells from nonobese diabetic (NOD) <--> C57BL/6 (B6) embryo aggregation (EA) chimeras into B6 and NOD irradiated mice. Insulitis and diabetes could be induced into both B6 and NOD hosts, albeit with low incidence. Cyclophosphamide (CY) treatment, known to accelerate diabetes in prediabetic NOD mice, was found to increase diabetes incidence up to 50-60% in both B6 and NOD mice reconstituted with chimeric splenocytes, while diabetes did not occur in CY-treated B6 mice reconstituted with B6 splenocytes. We conclude that the genetic make-up of the target organ does not affect the final stage of the pathogenesis of insulin-dependent diabetes mellitus.

Place, publisher, year, edition, pages
Wiley-Blackwell, 1998. Vol. 48, no 6, 571-576 p.
National Category
Basic Medicine
Research subject
Immunology
Identifiers
URN: urn:nbn:se:umu:diva-87509DOI: 10.1046/j.1365-3083.1998.00479.xPubMedID: 9874490OAI: oai:DiVA.org:umu-87509DiVA: diva2:709604
Available from: 2014-04-02 Created: 2014-04-02 Last updated: 2017-12-05Bibliographically approved

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Colucci, FrancescoBergman, Marie-LouiseLejon, KristinaHolmberg, Dan
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