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CTLA-4-/- mice display T cell-apoptosis resistance resembling that ascribed to autoimmune-prone non-obese diabetic (NOD) mice
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). (Department of Cell and Molecular Biology, University of Umeå, Umeå, Sweden)
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM). Endocrine Research Unit, Wallenberg Laboratory, Malmö University Hospital MAS, University of Lund, 205 02 Malmö Sweden. (Department of Cell and Molecular Biology, University of Umeå, Umeå, Sweden)
Instituto Gulbenkian de Ciencia, 2780, Oeiras, Portugal. (Department of Cell and Molecular Biology, University of Umeå, S-901 87, Umeå, Sweden)
INSERM U25, Hopital Necker, 75743, Paris, France.
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2001 (English)In: Journal of Autoimmunity, ISSN 0896-8411, E-ISSN 1095-9157, Vol. 16, no 2, 105-113 p.Article in journal (Refereed) Published
Abstract [en]

The genes conferring susceptibility to autoimmune (insulin-dependent) diabetes mellitus (IDDM) are, in most cases, not defined. Among the loci so far identified as associated with murine IDDM (Idd1-19), only the nature of Idd1 has been assessed. Here we show that thymocytes and peripheral lymphocytes of the non-obese diabetic (NOD) mouse are relatively resistant to apoptosis induced by gamma-irradiation. By linkage analysis of F2 progeny mice, we map this trait to a locus on chromosome 1 containing the Idd5 diabetes susceptibility region. By the use of congenic mice, we confirm the linkage data and map this locus to a 6 cM region on proximal chromosome 1. Ctla4, being localized in this chromosomal region and mediating crucial functions in T cell biology, is a logical candidate gene in the Idd5 susceptibility region. In line with this, we demonstrate that T cells from Ctla4(-/-)deficient mice show a similar resistance to gamma-irradiation-induced apoptosis as observed in the NOD mice. This reinforces the notion that CTLA-4 contributes to the pathogenesis of autoimmune diabetes.

Place, publisher, year, edition, pages
Elsevier, 2001. Vol. 16, no 2, 105-113 p.
National Category
Basic Medicine
Research subject
Immunology
Identifiers
URN: urn:nbn:se:umu:diva-87510DOI: 10.1006/jaut.2000.0474PubMedID: 11247636OAI: oai:DiVA.org:umu-87510DiVA: diva2:709608
Available from: 2014-04-02 Created: 2014-04-02 Last updated: 2017-12-05Bibliographically approved

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Löfgren, AnnaLejon, KristinaHolmberg, Dan

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Bergman, Marie-LouiseCilio, Corrado MLöfgren, AnnaColucci, FrancescoLejon, KristinaHolmberg, Dan
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Department of Molecular Biology (Faculty of Medicine)Umeå Centre for Molecular Medicine (UCMM)
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Journal of Autoimmunity
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