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The CD8alpha+ dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens.
Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia.
Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia.
Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia.
Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia.
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2002 (English)In: Journal of Experimental Medicine, ISSN 0022-1007, E-ISSN 1540-9538, Vol. 196, no 8, 1099-1104 p.Article in journal (Refereed) Published
Abstract [en]

We previously described a mechanism for the maintenance of peripheral self-tolerance. This involves the cross-presentation of tissue-associated antigens by a bone marrow-derived cell type that stimulates the proliferation and ultimate deletion of self-reactive CD8 T cells. This process has been referred to as cross-tolerance. Here, we characterize the elusive cell type responsible for inducing cross-tolerance as a CD8alpha(+) dendritic cell (DC). To achieve this aim, transgenic mice were generated expressing yellow fluorescent protein (YFP) linked to CTL epitopes for ovalbumin and glycoprotein B (gB) of herpes simplex virus under the rat insulin promoter (RIP). Although tracking of YFP was inconclusive, the use of a highly sensitive gB-specific hybridoma that produced beta-galactosidase on encounter with antigen, enabled detection of antigen presentation by cells isolated from the pancreatic lymph node. This showed that a CD11c(+)CD8alpha(+) cell was responsible for cross-tolerance, the same DC subset as previously implicated in cross-priming. These data indicate that CD8alpha(+) DCs play a critical role in both tolerance and immunity to cell-associated antigens, providing a potential mechanism by which cytotoxic T lymphocyte can be immunized to viral antigens while maintaining tolerance to self.

Place, publisher, year, edition, pages
The Rockefeller University Press , 2002. Vol. 196, no 8, 1099-1104 p.
National Category
Basic Medicine
Research subject
Immunology
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URN: urn:nbn:se:umu:diva-87524DOI: 10.1084/jem.20020861PubMedID: 12391021OAI: oai:DiVA.org:umu-87524DiVA: diva2:709633
Available from: 2014-04-02 Created: 2014-04-02 Last updated: 2017-12-05Bibliographically approved

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Lejon, Kristina

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CiteExportLink to record
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