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Non-obese diabetic (NOD) mice display enhanced immune responses and prolonged survival of lymphoid cells
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). (Department of Cell and Molecular Biology. University of Umeå)
SYMBICOM, Box 1451, S-901 24 Umeå, Sweden.
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). (Department of Cell and Molecular Biology. University of Umeå)
1994 (English)In: International Immunology, ISSN 0953-8178, E-ISSN 1460-2377, Vol. 6, no 2, 339-345 p.Article in journal (Refereed) Published
Abstract [en]

We report that lymphoid cells originating from the non-obese diabetic (NOD) autoimmune prone mouse strain are resistant to several signals known to induce programmed cell death. In vitro culturing of lymphoid cells of splenic or lymph node origin showed that B cells and T cells of both CD4+ and CD8+ phenotypes from NOD mice display extended survival in vitro. By cytofluorimetric analysis, immature CD4+ CD8+ NOD thymocytes were shown to partially resist in vivo treatment with corticosteroids. Finally, immunization with protein antigens induced enhanced and prolonged immune responses in NOD mice compared with normal C57BL/6, BALB/c, and C3H/Tif control mice. We conclude that the NOD mouse displays a defect in the mechanism(s) mediating programmed cell death in T and B lymphocytes. These findings provide a novel explanation for the B cell aberrations observed in the NOD mouse and may have implications for the understanding of the autoimmune pathogenesis in this mouse strain.

Place, publisher, year, edition, pages
Oxford: Oxford University Press, 1994. Vol. 6, no 2, 339-345 p.
National Category
Basic Medicine
Research subject
Immunology
Identifiers
URN: urn:nbn:se:umu:diva-87591DOI: 10.1093/intimm/6.2.339PubMedID: 8155606OAI: oai:DiVA.org:umu-87591DiVA: diva2:710126
Available from: 2014-04-04 Created: 2014-04-04 Last updated: 2017-12-05Bibliographically approved
In thesis
1. Cellular and genetic components in the development of IDDM in NOD mice.
Open this publication in new window or tab >>Cellular and genetic components in the development of IDDM in NOD mice.
1996 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Umeå: Umeå universitet, 1996. 80 p.
Series
Umeå University medical dissertations, ISSN 0346-6612 ; 464
Keyword
non-obese diabetic, IgVh gene utilisation, immunoregulation, programmed cell death, genetic linkage analysis
National Category
Basic Medicine
Research subject
Immunology
Identifiers
urn:nbn:se:umu:diva-87787 (URN)91-7191-150-2 (ISBN)
Public defence
1996-03-22, Institutionen för Mikrobiologi, föreläsningssalen, Umeå universitet, Umeå, 09:30
Supervisors
Available from: 2014-04-11 Created: 2014-04-09 Last updated: 2014-04-11Bibliographically approved

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