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Single nucleotide polymorphism analysis of corticotropin-releasing factor-binding protein gene in bipolar disorder
Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology ; Collaborative Antwerp Psychiatric Research Institute, University of Antwerp, Antwerp ; Department of Psychiatry, University Hospital Antwerp, Edegem.
Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology.
Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology.
Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology.
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2007 (English)In: Psychiatric Genetics, ISSN 0955-8829, E-ISSN 1473-5873, Vol. 17, no 5, 304-307 p.Article in journal (Refereed) Published
Abstract [en]

Corticotropin-releasing factor-binding protein regulates the availability of free corticotropin-releasing factor and is a functional candidate gene for affective disorders. The aim of this study was to examine the association between polymorphisms in CRF-BP gene and bipolar disorder in an isolated Swedish population. One hundred and eighty-two patients with bipolar I disorder and 333 controls from Northern Sweden were included in the study. Five single nucleotide polymorphisms and a deletion polymorphism in the CRF-BP gene were genotyped. The haplotype block structure of the gene was considered and the expectation maximization algorithm was adopted to estimate the haplotype frequencies. As a result, there were no significant associations of the different polymorphisms in the CRF-BP gene with bipolar disorder. In conclusion, this study in an isolated Swedish population does not support a role for the CRF-BP gene in the vulnerability for bipolar disorder.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2007. Vol. 17, no 5, 304-307 p.
Keyword [en]
bipolar disorder, corticotropin-releasing factor-binding protein, genetics, hypothalamic-pituitary-adrenal axis, vulnerability
National Category
Neurosciences Medical Genetics
Identifiers
URN: urn:nbn:se:umu:diva-87602DOI: 10.1097/YPG.0b013e328133f342ISI: 000249484300008PubMedID: 17728670OAI: oai:DiVA.org:umu-87602DiVA: diva2:710221
Available from: 2014-04-05 Created: 2014-04-05 Last updated: 2017-12-05

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CiteExportLink to record
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Citation style
  • apa
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  • de-DE
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