Single nucleotide polymorphism analysis of corticotropin-releasing factor-binding protein gene in bipolar disorder
2007 (English)In: Psychiatric Genetics, ISSN 0955-8829, E-ISSN 1473-5873, Vol. 17, no 5, 304-307 p.Article in journal (Refereed) Published
Corticotropin-releasing factor-binding protein regulates the availability of free corticotropin-releasing factor and is a functional candidate gene for affective disorders. The aim of this study was to examine the association between polymorphisms in CRF-BP gene and bipolar disorder in an isolated Swedish population. One hundred and eighty-two patients with bipolar I disorder and 333 controls from Northern Sweden were included in the study. Five single nucleotide polymorphisms and a deletion polymorphism in the CRF-BP gene were genotyped. The haplotype block structure of the gene was considered and the expectation maximization algorithm was adopted to estimate the haplotype frequencies. As a result, there were no significant associations of the different polymorphisms in the CRF-BP gene with bipolar disorder. In conclusion, this study in an isolated Swedish population does not support a role for the CRF-BP gene in the vulnerability for bipolar disorder.
Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2007. Vol. 17, no 5, 304-307 p.
bipolar disorder, corticotropin-releasing factor-binding protein, genetics, hypothalamic-pituitary-adrenal axis, vulnerability
Neurosciences Medical Genetics
IdentifiersURN: urn:nbn:se:umu:diva-87602DOI: 10.1097/YPG.0b013e328133f342ISI: 000249484300008PubMedID: 17728670OAI: oai:DiVA.org:umu-87602DiVA: diva2:710221