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Lack of association of an insertion/deletion polymorphism in the G protein-coupled receptor 50 with bipolar disorder in a Northern Swedish population
Applied Molecular Genomics Group, Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology (VIB), University of Antwerp (UA), Belgium.
Applied Molecular Genomics Group, Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology (VIB), University of Antwerp (UA), Belgium.
Applied Molecular Genomics Group, Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology (VIB), University of Antwerp (UA), Belgium.
Applied Molecular Genomics Group, Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology (VIB), University of Antwerp (UA), Belgium.
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2006 (English)In: Psychiatric Genetics, ISSN 0955-8829, E-ISSN 1473-5873, Vol. 16, no 6, 235-236 p.Article in journal (Refereed) Published
Abstract [en]

GPR50 is a G protein-coupled receptor, located on Xq28 and related to the melatonin receptor family. It is suggested as a functional and positional candidate gene for bipolar disorder (BP). Recently an insertion/deletion polymorphism in GPR50, Delta502-505, was found to be associated with BP in a Scottish association sample (P=0.007). When the analysis was restricted to female subjects, the association increased in significance (P=0.00023). We attempted to replicate this finding in a Northern Swedish association sample, but no significant association was detected (P=0.7, women only: P=0.65).

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2006. Vol. 16, no 6, 235-236 p.
Keyword [en]
GPR50, G protein-coupled receptor, bipolar disorder, association study, genotyping
National Category
Neurosciences Medical Genetics
Identifiers
URN: urn:nbn:se:umu:diva-87604DOI: 10.1097/01.ypg.0000242193.28526.b3ISI: 000242680800006PubMedID: 17106423OAI: oai:DiVA.org:umu-87604DiVA: diva2:710223
Available from: 2014-04-05 Created: 2014-04-05 Last updated: 2017-12-05

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