Lack of association of an insertion/deletion polymorphism in the G protein-coupled receptor 50 with bipolar disorder in a Northern Swedish population
2006 (English)In: Psychiatric Genetics, ISSN 0955-8829, E-ISSN 1473-5873, Vol. 16, no 6, 235-236 p.Article in journal (Refereed) Published
GPR50 is a G protein-coupled receptor, located on Xq28 and related to the melatonin receptor family. It is suggested as a functional and positional candidate gene for bipolar disorder (BP). Recently an insertion/deletion polymorphism in GPR50, Delta502-505, was found to be associated with BP in a Scottish association sample (P=0.007). When the analysis was restricted to female subjects, the association increased in significance (P=0.00023). We attempted to replicate this finding in a Northern Swedish association sample, but no significant association was detected (P=0.7, women only: P=0.65).
Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2006. Vol. 16, no 6, 235-236 p.
GPR50, G protein-coupled receptor, bipolar disorder, association study, genotyping
Neurosciences Medical Genetics
IdentifiersURN: urn:nbn:se:umu:diva-87604DOI: 10.1097/01.ypg.0000242193.28526.b3ISI: 000242680800006PubMedID: 17106423OAI: oai:DiVA.org:umu-87604DiVA: diva2:710223