No allelic association or interaction of three known functional polymorphisms with bipolar disorder in a northern Swedish isolated population
2006 (English)In: Psychiatric Genetics, ISSN 0955-8829, E-ISSN 1473-5873, Vol. 16, no 5, 209-212 p.Article in journal (Refereed) Published
Most genetic association studies in bipolar disorder have focussed on genes involved in major neurotransmitter systems or brain development. Functional polymorphisms in the serotonin transporter (5-HTTLPR), catechol-O-methyltransferase (Val158Met) and dopamine D3 receptor (Ser9Gly) genes have all been associated with bipolar disorder. We aimed at investigating whether these functional variants contribute to the genetic etiology of bipolar disorder in a northern Swedish isolated population. Moreover, we wanted to gain information about the synergistic contribution of these functional variants. Neither of these functional polymorphisms was associated with bipolar disorder in the northern Swedish patient-control sample nor did we find evidence of gene-gene interaction. Together, our data suggest that these functional variants are not involved in the etiology of bipolar disorder in the northern Swedish population nor did gene-gene interaction analysis support a central role of these variants in bipolar disorder.
Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2006. Vol. 16, no 5, 209-212 p.
association study, bipolar disorder, catechol-O-methyltransferase, dopamine D3 receptor, interaction study, serotonin transporter
Medical Genetics Neurosciences
IdentifiersURN: urn:nbn:se:umu:diva-87606DOI: 10.1097/01.ypg.0000218623.03752.e4ISI: 000241389700009PubMedID: 16969276OAI: oai:DiVA.org:umu-87606DiVA: diva2:710225