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Multispectral guided fluorescence diffuse optical tomography using upconverting nanoparticles
Umeå University, Faculty of Science and Technology, Department of Physics. Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). Department of Physics, Lund University.
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2014 (English)In: Applied Physics Letters, ISSN 0003-6951, E-ISSN 1077-3118, Vol. 104, no 7, 073703- p.Article in journal (Refereed) Published
Abstract [en]

We report on improved image detectability for fluorescence diffuse optical tomography using upconverting nanoparticles doped with rare-earth elements. Core-shell NaYF4 : Yb3+/Er3+ @ NaYF4 upconverting nanoparticles were synthesized through a stoichiometric method. The Yb3+/Er3+ sensitizer-activator pair yielded two anti-Stokes shifted fluorescence emission bands at 540 nm and 660 nm, here used to a priori estimate the fluorescence source depth with sub-millimeter precision. A spatially varying regularization incorporated the a priori fluorescence source depth estimation into the tomography reconstruction scheme. Tissue phantom experiments showed both an improved resolution and contrast in the reconstructed images as compared to not using any a priori information.

Place, publisher, year, edition, pages
2014. Vol. 104, no 7, 073703- p.
National Category
Physical Sciences
URN: urn:nbn:se:umu:diva-87649DOI: 10.1063/1.4863960ISI: 000332038500085OAI: diva2:710931
Available from: 2014-04-08 Created: 2014-04-07 Last updated: 2014-04-08Bibliographically approved

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Svenmarker, Pontus
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