Change search
ReferencesLink to record
Permanent link

Direct link
Genomic Analysis of Sexual Dimorphism of Gene Expression in the Mouse Adrenal Gland
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). CNRS, Inst Pharmacol Mol & Cellulaire, 660 Route Lucioles, F-06560 Valbonne, France.
2013 (English)In: Hormone and Metabolic Research, ISSN 0018-5043, E-ISSN 1439-4286, Vol. 45, no 12, 870-873 p.Article in journal (Refereed) Published
Abstract [en]

A relevant gender difference exists in adrenal physiology and propensity to disease. In mice, a remarkable sexual dimorphism is present in several components of the hypothalamic-pituitary-adrenal axis, with females displaying higher adrenal weight, plasma ACTH, corticosterone, and aldosterone levels than males. The molecular bases of this sexual dimorphism are little known. We have compared global gene expression profiles in males vs. female mouse adrenal glands and also studied the effect that testosterone treatment and castration have on adrenal gene expression in female vs. male mice, respectively. Our study evidenced a set of 71 genes that are coordinately modulated according to sex and hormonal treatments and represent the core sexually dimorphic expression program in the mouse adrenal gland. Moreover, we show that some genes involved in steroid metabolism have a remarkable sexual dimorphic expression and identify new potential markers for the adrenal X-zone, a transitory cellular layer in the inner adrenal cortex, which spontaneously regresses at puberty in males and during the first pregnancy in females and has an uncertain physiological role. Finally, sexually dimorphic expression of the transcriptional regulators Nr5a1 and Nr0b1 may explain at least in part the differences in adrenal steroidogenesis between sexes.

Place, publisher, year, edition, pages
2013. Vol. 45, no 12, 870-873 p.
Keyword [en]
genomics, gene expression, adrenal gland
National Category
Medical and Health Sciences
URN: urn:nbn:se:umu:diva-88419DOI: 10.1055/s-0033-1349881ISI: 000333484900005OAI: diva2:715696
Available from: 2014-05-06 Created: 2014-05-05 Last updated: 2014-05-06Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
El Wakil, Abeer
By organisation
Department of Molecular Biology (Faculty of Medicine)
In the same journal
Hormone and Metabolic Research
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 77 hits
ReferencesLink to record
Permanent link

Direct link