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A cis-encoded sRNA controls the expression of fabH2 in Yersinia
Chinese Academy of Sciences, Wuhan, China.
Chinese Academy of Sciences, Wuhan, China.
Chinese Academy of Sciences, Wuhan, China.
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology). Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). (Matthew Francis)
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2014 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 588, no 10, 1961-1966 p.Article in journal (Refereed) Published
Abstract [en]

YsrH is a novel cis-encoded sRNA located on the opposite strand to fabH2, which is essential for fatty acid biosynthesis in bacteria. In this study, YsrH-mediated regulation of fabH2 expression was investigated in Yersinia pseudotuberculosis. Constitutive and inducible over-expression of YsrH decreased the mRNA level of fabH2, while expression of downstream fabD and fabG remained unaffected. Polynucleotide phosphorylase (PNPase) also played an important role in this regulation process by mediating YsrH decay in the exponential phase. Thus, our data defines a cis-encoded sRNA that regulates fatty acid synthesis via a regulatory mechanism also involving PNPase.

Place, publisher, year, edition, pages
2014. Vol. 588, no 10, 1961-1966 p.
Keyword [en]
3-oxoacyl-ACP synthase (fabH2); Yersinia sRNA regulator of fabH2 (YsrH); cis-Encoded sRNA; PNPase; Yersinia
National Category
Microbiology Biochemistry and Molecular Biology
Research subject
Microbiology; Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-88605DOI: 10.1016/j.febslet.2014.04.005ISI: 000336033700016PubMedID: 24735725OAI: oai:DiVA.org:umu-88605DiVA: diva2:716500
Available from: 2014-05-09 Created: 2014-05-09 Last updated: 2017-12-05Bibliographically approved

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Publisher's full textPubMedhttp://dx.doi.org/10.1016/j.febslet.2014.04.005

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Department of Molecular Biology (Faculty of Science and Technology)Umeå Centre for Microbial Research (UCMR)
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CiteExportLink to record
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