A cis-encoded sRNA controls the expression of fabH2 in Yersinia
2014 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 588, no 10, 1961-1966 p.Article in journal (Refereed) Published
YsrH is a novel cis-encoded sRNA located on the opposite strand to fabH2, which is essential for fatty acid biosynthesis in bacteria. In this study, YsrH-mediated regulation of fabH2 expression was investigated in Yersinia pseudotuberculosis. Constitutive and inducible over-expression of YsrH decreased the mRNA level of fabH2, while expression of downstream fabD and fabG remained unaffected. Polynucleotide phosphorylase (PNPase) also played an important role in this regulation process by mediating YsrH decay in the exponential phase. Thus, our data defines a cis-encoded sRNA that regulates fatty acid synthesis via a regulatory mechanism also involving PNPase.
Place, publisher, year, edition, pages
2014. Vol. 588, no 10, 1961-1966 p.
3-oxoacyl-ACP synthase (fabH2); Yersinia sRNA regulator of fabH2 (YsrH); cis-Encoded sRNA; PNPase; Yersinia
Microbiology Biochemistry and Molecular Biology
Research subject Microbiology; Molecular Biology
IdentifiersURN: urn:nbn:se:umu:diva-88605DOI: 10.1016/j.febslet.2014.04.005ISI: 000336033700016PubMedID: 24735725OAI: oai:DiVA.org:umu-88605DiVA: diva2:716500