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High serum phosphate and triglyceride levels in smoking women and men with CVD risk and type 2 diabetes
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Family Medicine.
Animal Health Care, Hällnäs 4, Vännäs SE- 911 94, Sweden.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Family Medicine.
2014 (English)In: Diabetology and Metabolic Syndrome, ISSN 1758-5996, Vol. 6, 39- p.Article in journal (Refereed) Published
Abstract [en]

Background: Both low and high serum phosphate levels may be associated with morbidity and mortality from cardiovascular disease. As smoking increases risk for type 2 diabetes (as shown by dyslipidemia and hyperglycemia), we wanted to study whether smoking and type 2 diabetes were associated with serum phosphate and triglyceride levels independently from other CVD risk factors. Methods: Upon admittance to the Vindeln Health Education Centre (VHE-centre) for a four-week comprehensive lifestyle intervention, the participants (1408 women and 1096 men) completed a questionnaire that included their smoking habits - current smoker or non-smoker. We used multiple linear regression analyses to investigate the association between smoking and other CVD risk factors with S-P and S-TG levels. Results: In the non-type 2 diabetes populations, the smokers, compared to the non-smokers, had higher S-P and higher serum triglycerides (S-TG). In women, serum-TG in smokers with type 2 diabetes was higher than in smokers with non-type 2 diabetes. Non-type 2 diabetes patients exhibited an inverse relation between S-Glucose (S-Glu) and S-P and a positive association with S-TG. For men only, an association was seen between age (-) and S-Crea (-) and S-P. For women only, an association was seen between BMI (-) and S-Cholesterol (+) (S-Chol) and S-P. Conclusions: Compared to non-smokers, smoking women with non-type 2 diabetes and smoking men with type 2 diabetes had a higher level of S-P and S-TG. The association between smoking and S-P and S-TG levels still existed after adjusting for age and CVD risk factors in the multiple linear regression analyses.

Place, publisher, year, edition, pages
BioMed Central, 2014. Vol. 6, 39- p.
Keyword [en]
Glucose intolerance, Obesity, Risk factors, Gender, Phosphate, Smoking
National Category
Endocrinology and Diabetes
URN: urn:nbn:se:umu:diva-88964DOI: 10.1186/1758-5996-6-39ISI: 000334615400002OAI: diva2:719014
Available from: 2014-05-22 Created: 2014-05-19 Last updated: 2014-05-22Bibliographically approved

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