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Transcription Factor Activating Protein-2 beta (TFAP-2 beta) genotype and symptoms of attention deficit hyperactivity disorder in relation to symptoms of depression in two independent samples
Centre for Clinical Research, Västmanland County Hospital, Uppsala University, 721 89, Västerås, Sweden.
Centre for Clinical Research, Västmanland County Hospital, Uppsala University, 721 89, Västerås, Sweden.
Department of Neuroscience, Uppsala University, POB 593, 751 24, Uppsala, Sweden.
Department of Neuroscience, Uppsala University, POB 593, 751 24, Uppsala, Sweden.
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2014 (English)In: European Child and Adolescent Psychiatry, ISSN 1018-8827, E-ISSN 1435-165X, Vol. 23, no 4, 207-217 p.Article in journal (Refereed) Published
Abstract [en]

The Transcription Factor Activating Protein-2 beta (TFAP-2 beta) gene has been shown to influence monoaminergic neurotransmission, and several genes important for monoaminergic function have binding sites for TFAP-2 beta. Familial studies of attention deficit hyperactivity disorder (ADHD) suggest a hereditary-determined subtype of ADHD with comorbid depression. We examined a functional variation of the TFAP-2 beta gene in the context of co-occurring symptoms of ADHD and depression in two independent population-based samples of adolescents (Group A, n = 175 and Group B, n = 1,506) from Sweden. Results indicated 6.1 to 7.8 % of adolescents screened positively for ADHD and depression symptoms. Symptoms of depression were more common among girls who screened positively for ADHD and did not carry the nine-repeat allele of the TFAP-2 beta intron 1 Variable Number Tandem Repeat (VNTR) polymorphism. The presence of the nine-repeat variant of the TFAP-2 beta intron 1 VNTR appears to protect girls with ADHD symptoms from the co-expression of symptoms of depression.

Place, publisher, year, edition, pages
Berlin Heidelberg: Springer Berlin/Heidelberg, 2014. Vol. 23, no 4, 207-217 p.
Keyword [en]
ADHD, Adolescents, Comorbidity, Depression, Gene-environment interaction, Transcription factor AP-2 beta
National Category
Neurosciences
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URN: urn:nbn:se:umu:diva-88956DOI: 10.1007/s00787-013-0450-6ISI: 000334175700004OAI: oai:DiVA.org:umu-88956DiVA: diva2:719190
Available from: 2014-05-23 Created: 2014-05-19 Last updated: 2017-12-05Bibliographically approved

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Sjöberg, Rickard L.

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