The interaction between smoking and Epstein-Barr virus as multiple sclerosis risk factors may depend on age
2014 (English)In: Multiple Sclerosis, ISSN 1352-4585, E-ISSN 1477-0970, Vol. 20, no 6, 747-750 p.Article in journal (Refereed) Published
The multiple sclerosis (MS) risk factors smoking and remote Epstein-Barr virus (EBV) infection have been suggested to interact statistically, but the results are conflicting. In a prospective study on 192 MS cases and 384 matched controls, we analysed levels of cotinine as a marker of smoke exposure, and Epstein-Barr Nuclear Antigen-1 antibody reactivity. We assessed interaction on the additive and multiplicative scales, and estimated the effects of the risk factors across strata of each other. The results suggest that a negative interaction may be present in samples drawn at a young age, and a positive interaction among older subjects.
Place, publisher, year, edition, pages
Sage Publications, 2014. Vol. 20, no 6, 747-750 p.
Epstein-Barr virus, case control study, interaction, risk factors in epidemiology, smoking, Multiple sclerosis
IdentifiersURN: urn:nbn:se:umu:diva-89213DOI: 10.1177/1352458513507820ISI: 000334865900014OAI: oai:DiVA.org:umu-89213DiVA: diva2:720203