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Infant body composition and adipokine concentrations in relation to maternal gestational weight gain
Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Skåne University Hospital, Lund University, Malmö, Sweden .
Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Skåne University Hospital, Lund University, Malmö, Sweden ; Phoenix Epidemiology and Clinical Research Branch, National Institutes of Health, Phoenix, AZ .
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine. Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Skåne University Hospital, Lund University, Malmö, Sweden . (Genetic Epidemiology and Clinical Research Group)
Reproductive and Maternal Medicine, Faculty of Medicine, University of Glasgow, Glasgow, U.K..
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2014 (English)In: Diabetes Care, ISSN 0149-5992, E-ISSN 1935-5548, Vol. 37, no 5, 1432-1438 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To investigate associations of maternal gestational weight gain and body composition and their impact on offspring body composition and adipocytokine, glucose, and insulin concentrations at age 4 months. RESEARCH DESIGN AND METHODS: This was a prospective study including 31 mother-infant pairs (N = 62). Maternal body composition was assessed using doubly labeled water. Infant body composition was assessed at 4 months using air displacement plethysmography, and venous blood was assayed for glucose, insulin, adiponectin, interleukin-6 (IL-6), and leptin concentrations. RESULTS: Rate of gestational weight gain in midpregnancy was significantly associated with infant fat mass (r = 0.41, P = 0.03); rate of gestational weight in late pregnancy was significantly associated with infant fat-free mass (r = 0.37, P = 0.04). Infant birth weight was also strongly correlated with infant fat-free mass at 4 months (r = 0.63, P = 0.0002). Maternal BMI and maternal fat mass were strongly inversely associated with infant IL-6 concentrations (r = -0.60, P = 0.002 and r = -0.52, P = 0.01, respectively). Infant fat-free mass was inversely related to infant adiponectin concentrations (r = -0.48, P = 0.008) and positively correlated with infant blood glucose adjusted for insulin concentrations (r = 0.42, P = 0.04). No significant associations for leptin were observed. CONCLUSIONS: Timing of maternal weight gain differentially impacts body composition of the 4-month-old infant, which in turn appears to affect the infant's glucose and adipokine concentrations.

Place, publisher, year, edition, pages
American Diabetes Association , 2014. Vol. 37, no 5, 1432-1438 p.
National Category
Endocrinology and Diabetes
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URN: urn:nbn:se:umu:diva-89210DOI: 10.2337/dc13-2265ISI: 000334840100060OAI: oai:DiVA.org:umu-89210DiVA: diva2:720224
Available from: 2014-05-28 Created: 2014-05-26 Last updated: 2017-12-05Bibliographically approved

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Renström, FridaMogren, IngridPersson, MargaretaDomellöf, MagnusFranks, Paul W.
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