N-acylated derivatives of sulfamethoxazole and sulfafurazole inhibit intracellular growth of Chlamydia trachomatis
2014 (English)In: Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, E-ISSN 1098-6596, Vol. 58, no 5, 2968-2971 p.Article in journal (Refereed) Published
Antibacterial compounds with novel modes of action are needed for management of bacterial infections. Here we describe a high-content screen of 9,800 compounds identifying acylated sulfonamides as novel growth inhibitors of the sexually transmitted pathogen Chlamydia trachomatis. The effect was bactericidal and distinct from that of sulfonamide antibiotics, as para-aminobenzoic acid did not reduce efficacy. Chemical inhibitors play an important role in Chlamydia research as probes of potential targets and as drug development starting points.
Place, publisher, year, edition, pages
American Society for Microbiology , 2014. Vol. 58, no 5, 2968-2971 p.
Pharmaceutical Sciences Pharmacology and Toxicology Microbiology in the medical area
IdentifiersURN: urn:nbn:se:umu:diva-89208DOI: 10.1128/AAC.02015-13ISI: 000334364300064OAI: oai:DiVA.org:umu-89208DiVA: diva2:720253