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N-acylated derivatives of sulfamethoxazole and sulfafurazole inhibit intracellular growth of Chlamydia trachomatis
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Umeå University, Faculty of Science and Technology, Department of Chemistry. (Laboratories for Chemical Biology Umeå, LCBU)
Umeå University, Faculty of Science and Technology, Department of Chemistry. Umeå University, Faculty of Medicine, Department of Clinical Microbiology.
Umeå University, Faculty of Science and Technology, Department of Chemistry.
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2014 (English)In: Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, E-ISSN 1098-6596, Vol. 58, no 5, 2968-2971 p.Article in journal (Refereed) Published
Abstract [en]

Antibacterial compounds with novel modes of action are needed for management of bacterial infections. Here we describe a high-content screen of 9,800 compounds identifying acylated sulfonamides as novel growth inhibitors of the sexually transmitted pathogen Chlamydia trachomatis. The effect was bactericidal and distinct from that of sulfonamide antibiotics, as para-aminobenzoic acid did not reduce efficacy. Chemical inhibitors play an important role in Chlamydia research as probes of potential targets and as drug development starting points.

Place, publisher, year, edition, pages
American Society for Microbiology , 2014. Vol. 58, no 5, 2968-2971 p.
National Category
Pharmaceutical Sciences Pharmacology and Toxicology Microbiology in the medical area
Identifiers
URN: urn:nbn:se:umu:diva-89208DOI: 10.1128/AAC.02015-13ISI: 000334364300064OAI: oai:DiVA.org:umu-89208DiVA: diva2:720253
Available from: 2014-05-28 Created: 2014-05-26 Last updated: 2017-12-05Bibliographically approved

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Marwaha, SaniaUvell, HannaSalin, OlliLindgren, Anders E. G.Silver, JimElofsson, MikaelGylfe, Åsa
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Department of ChemistryDepartment of Clinical MicrobiologyDepartment of Molecular Biology (Faculty of Medicine)Umeå Centre for Microbial Research (UCMR)Molecular Infection Medicine Sweden (MIMS)Clinical Bacteriology
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Antimicrobial Agents and Chemotherapy
Pharmaceutical SciencesPharmacology and ToxicologyMicrobiology in the medical area

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CiteExportLink to record
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