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Dopamine release in nucleus accumbens during rewarded task switching measured by [11C]raclopride
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Radiation Sciences. Umeå University, Faculty of Social Sciences, Centre for Population Studies (CPS).
Umeå University, Faculty of Medicine, Department of Radiation Sciences. Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
Umeå University, Faculty of Medicine, Department of Radiation Sciences.
Department of Psychology,Washington University, St Louis, MO 63130, USA.
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2014 (English)In: NeuroImage, ISSN 1053-8119, E-ISSN 1095-9572, Vol. 99, p. 357-364Article in journal (Refereed) Published
Abstract [en]

Reward and motivation have positive influences on cognitive-control processes in numerous settings. Models of reward implicate corticostriatal loops and the dopamine (DA) system, with special emphasis on D2 receptors in nucleus accumbens (NAcc). In this study, 11 right-handed males (35-40 years) were scanned with positron emission tomography (PET) in a single [(11)C]raclopride dynamic scan during rewarded and non-rewarded task switching. Rewarded task switching (relative to baseline task switching) decreased [(11)C]raclopride binding in NAcc. Decreasing NAcc [(11)C]raclopride binding was strongly associated with task reaction time measures that reflect individual differences in effort and control strategies. Voxelwise analyses additionally revealed reward-related DA release in anterodorsal caudate, a region previously associated with task-switching. These PET findings provide evidence for striatal DA release during motivated cognitive control, and further suggest that NAcc DA release predicts the task reaction time benefits of reward incentives.

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 99, p. 357-364
Keyword [en]
Reward, Dopamine, PET, Nucleus accumbens, Working memory, Motivation
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:umu:diva-89529DOI: 10.1016/j.neuroimage.2014.05.047ISI: 000339860000036PubMedID: 24862078OAI: oai:DiVA.org:umu-89529DiVA, id: diva2:721348
Available from: 2014-06-04 Created: 2014-06-04 Last updated: 2018-02-13Bibliographically approved

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Jonasson, Lars S.Axelsson, JanRiklund, KatrineÖgren, MattiasNyberg, Lars
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