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Accurate macromolecular structures using minimal measurements from X-ray free-electron lasers
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2014 (English)In: Nature Methods, ISSN 1548-7091, E-ISSN 1548-7105, Vol. 11, no 5, 545-548 p.Article in journal (Refereed) Published
Abstract [en]

X-ray free-electron laser (XFEL) sources enable the use of crystallography to solve three-dimensional macromolecular structures under native conditions and without radiation damage. Results to date, however, have been limited by the challenge of deriving accurate Bragg intensities from a heterogeneous population of microcrystals, while at the same time modeling the X-ray spectrum and detector geometry. Here we present a computational approach designed to extract meaningful high-resolution signals from fewer diffraction measurements.

Place, publisher, year, edition, pages
2014. Vol. 11, no 5, 545-548 p.
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Atom and Molecular Physics and Optics
URN: urn:nbn:se:umu:diva-90083DOI: 10.1038/NMETH.2887ISI: 000335873400020OAI: diva2:727122
Available from: 2014-06-19 Created: 2014-06-17 Last updated: 2014-06-19Bibliographically approved

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Sellberg, JonasMessinger, Johannes
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Department of Chemistry
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