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Warfarin-Associated Intracerebral Hemorrhage After Ischemic Stroke
Department of Medical Sciences, Uppsala University, SE-75185 Uppsala, Sweden.
Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Statistics.ORCID iD: 0000-0003-3298-1555
Department of Medical Sciences, Uppsala University, SE-75185 Uppsala, Sweden; AstraZeneca R&D, Mölndal, Sweden.
Department of Medical Sciences, Uppsala University, SE-75185 Uppsala, Sweden.
2014 (English)In: Stroke, ISSN 0039-2499, E-ISSN 1524-4628, Vol. 45, no 7, 2118-2120 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND AND PURPOSE: The aim was to investigate the risk of intracerebral hemorrhage (ICH) in patients with ischemic stroke taking warfarin and whether this risk changed over time.

METHODS: Between 2001 and 2008, the Swedish Stroke Register registered 12 790 patients with ischemic stroke discharged on warfarin. The patients was studied in two 4-year periods (inclusion 2001-2004: follow-up until 2005 and inclusion 2005-2008: follow-up until 2009) for which rates of subsequent ICH were calculated. Adjusted hazard ratios, comparing the second period with the first period, were estimated in Cox regression models.

RESULTS: Of 6039 patients, 58 patients (1.0%) in the first period and 69 of 6751 patients (1.0%) in the second period had subsequent ICH. Annual rates of ICH ranged from 0.37% in the first period to 0.39% in the second period (adjusted hazard ratio, 1.04; 95% confidence interval, 0.73-1.48).

CONCLUSIONS: In this nationwide study, the risk of warfarin-associated ICH among ischemic stroke patients was low and did not change during the 2000s.

Place, publisher, year, edition, pages
American Heart Association , 2014. Vol. 45, no 7, 2118-2120 p.
Keyword [en]
anticoagulants, stroke
National Category
Neurology Cardiac and Cardiovascular Systems
URN: urn:nbn:se:umu:diva-90355DOI: 10.1161/STROKEAHA.114.005729ISI: 000338129400045PubMedID: 24876246OAI: diva2:727315
Available from: 2014-06-19 Created: 2014-06-19 Last updated: 2016-05-02Bibliographically approved

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