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Warfarin-Associated Intracerebral Hemorrhage After Ischemic Stroke
Department of Medical Sciences, Uppsala University, SE-75185 Uppsala, Sweden.
Umeå universitet, Samhällsvetenskapliga fakulteten, Handelshögskolan vid Umeå universitet, Statistik.ORCID-id: 0000-0003-3298-1555
Department of Medical Sciences, Uppsala University, SE-75185 Uppsala, Sweden; AstraZeneca R&D, Mölndal, Sweden.
Department of Medical Sciences, Uppsala University, SE-75185 Uppsala, Sweden.
2014 (Engelska)Ingår i: Stroke, ISSN 0039-2499, E-ISSN 1524-4628, Vol. 45, nr 7, s. 2118-2120Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

BACKGROUND AND PURPOSE: The aim was to investigate the risk of intracerebral hemorrhage (ICH) in patients with ischemic stroke taking warfarin and whether this risk changed over time.

METHODS: Between 2001 and 2008, the Swedish Stroke Register registered 12 790 patients with ischemic stroke discharged on warfarin. The patients was studied in two 4-year periods (inclusion 2001-2004: follow-up until 2005 and inclusion 2005-2008: follow-up until 2009) for which rates of subsequent ICH were calculated. Adjusted hazard ratios, comparing the second period with the first period, were estimated in Cox regression models.

RESULTS: Of 6039 patients, 58 patients (1.0%) in the first period and 69 of 6751 patients (1.0%) in the second period had subsequent ICH. Annual rates of ICH ranged from 0.37% in the first period to 0.39% in the second period (adjusted hazard ratio, 1.04; 95% confidence interval, 0.73-1.48).

CONCLUSIONS: In this nationwide study, the risk of warfarin-associated ICH among ischemic stroke patients was low and did not change during the 2000s.

Ort, förlag, år, upplaga, sidor
American Heart Association , 2014. Vol. 45, nr 7, s. 2118-2120
Nyckelord [en]
anticoagulants, stroke
Nationell ämneskategori
Neurologi Kardiologi
Identifikatorer
URN: urn:nbn:se:umu:diva-90355DOI: 10.1161/STROKEAHA.114.005729ISI: 000338129400045PubMedID: 24876246OAI: oai:DiVA.org:umu-90355DiVA, id: diva2:727315
Tillgänglig från: 2014-06-19 Skapad: 2014-06-19 Senast uppdaterad: 2018-06-07Bibliografiskt granskad

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