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Free beta- human chorionic gonadotropin, total human chorionic gonadotropin and maternal risk of breast cancer
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
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2014 (English)In: Future Oncology, ISSN 1479-6694, E-ISSN 1744-8301, Vol. 10, no 3, 377-384 p.Article in journal (Refereed) Published
Abstract [en]

Background: We investigated whether the free -human chorionic gonadotropin (free -hCG) would provide additional information to that provided by total hCG alone and thus be useful in future epidemiological studies relating hCG to maternal breast cancer risk. Materials & methods: Cases (n = 159) and controls (n = 286) were a subset of our previous study within the Northern Sweden Maternity Cohort on total hCG during primiparous pregnancy and breast cancer risk. Results: The associations between total hCG (hazard ratio: 0.79; 95% CI: 0.49-1.27), free -hCG (hazard ratio: 0.85; 95% CI: 0.33-2.18) and maternal risk of breast cancer were very similar in all analyses and mutual adjustment for either one had minor effects on the risk estimates. Conclusion: In the absence of a reliable assay on intact hCG, total hCG alone can be used in epidemiological studies investigating hCG and breast cancer risk, as free -hCG does not appear to provide any additional information.

Place, publisher, year, edition, pages
2014. Vol. 10, no 3, 377-384 p.
Keyword [en]
breast cancer, free -human chorionic gonadotropin, human chorionic gonadotropin, nested case-control study, pregnancy
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-90464DOI: 10.2217/FON.13.208ISI: 000331698600011OAI: oai:DiVA.org:umu-90464DiVA: diva2:733008
Available from: 2014-07-07 Created: 2014-06-23 Last updated: 2017-12-05Bibliographically approved

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Tolockiene, EgleSchock, HelenaWadell, GöranLundin, EvaGrankvist, KjellLukanova, Annekatrin
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CiteExportLink to record
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