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Antisecretory factor effectively and safely stops childhood diarrhoea: a placebo-controlled, randomised study
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2014 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 103, no 6, 659-664 p.Article in journal (Refereed) Published
Abstract [en]

Aim

We studied the response to high doses of egg yolk containing antisecretory factor (B221((R)), Salovum((R))) in young children with acute diarrhoea, presenting to the Children's Hospital, Lahore, Pakistan.

Methods

In a randomised, placebo-controlled trial, 36 children aged 7 to 60months with acute diarrhoea of unknown aetiology, with mild-to-moderate dehydration, were randomised to the Salovum((R)) or placebo groups. Initially, 16 grams of Salovum((R)) or ordinary egg yolk (placebo) mixed in oral rehydration salts was given, followed by 8g every 5h until recovery. The number and consistency of stools were recorded.

Results

The two groups were comparable in age, gender, duration of diarrhoea, hydration and nutritional status, although the proportion with watery stools was higher in the Salovum((R)) group (p=0.04). Reduction in the frequency of stools was seen at 7 versus 18h (p<0.0001) and normalising of stool consistency was 10 versus 18h, p<0.03) in the Salovum((R)) and placebo groups. The overall effect was 35 versus 70h in the two groups (p=0.001). No side effects were reported.

Conclusion

High doses of AF in the form of Salovum((R)) effectively and safely reduce childhood diarrhoea of a likely broad aetiology.

Place, publisher, year, edition, pages
2014. Vol. 103, no 6, 659-664 p.
Keyword [en]
Antisecretory factor, Developing country, Diarrhoeal disease, Paediatric patients
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:umu:diva-90408DOI: 10.1111/apa.12581ISI: 000335754700024OAI: oai:DiVA.org:umu-90408DiVA: diva2:733580
Available from: 2014-07-10 Created: 2014-06-23 Last updated: 2017-12-05Bibliographically approved

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CiteExportLink to record
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Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
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  • asciidoc
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