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The APOE epsilon 4 allele in relation to brain white-matter microstructure in adulthood and aging
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Physiology. Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
2014 (English)In: Scandinavian Journal of Psychology, ISSN 0036-5564, E-ISSN 1467-9450, Vol. 55, no 3, 263-267 p.Article in journal (Refereed) Published
Abstract [en]

The Apolipoprotein E (ApoE) epsilon 4 allele is a major genetic risk factor for sporadic Alzheimer's disease and has been associated with structural and functional brain alterations across the adult life span. Recent studies have presented evidence that epsilon 4 affects microstructural properties of brain white matter (WM) in non-demented carriers of the epsilon 4 allele, but conflicting evidence has been presented as well. The main purpose of the present study was therefore to examine ApoE effects on WM in a large sample of middle-aged and older adults (N=273). Diffusion tensor imaging (DTI) data was acquired, and tract-based as well as voxel-wise analyses were conducted. The tract-based analyses revealed no significant ApoE effects, and no significant interactions between genotype and age were observed. Taken together, the findings of the present study suggest that ApoE effects on white-matter microstructure are less abundant than has been suggested in some previous studies.

Place, publisher, year, edition, pages
2014. Vol. 55, no 3, 263-267 p.
Keyword [en]
Brain, white matter, DTI, ApoE
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:umu:diva-91148DOI: 10.1111/sjop.12099ISI: 000337518200011OAI: oai:DiVA.org:umu-91148DiVA: diva2:734406
Available from: 2014-07-17 Created: 2014-07-15 Last updated: 2017-12-05Bibliographically approved

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Nyberg, LarsSalami, Alireza

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