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Regenerative effects of adipose-tissue-derived stem cells for treatment of peripheral nerve injuries
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy. Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Hand Surgery.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy.
2014 (English)In: Biochemical Society Transactions, ISSN 0300-5127, E-ISSN 1470-8752, Vol. 42, 697-701 p.Article in journal (Refereed) Published
Abstract [en]

Peripheral nerve injuries are a common occurrence affecting the nerves found outside the central nervous system. Complete nerve transections necessitate surgical re-anastomosis, and, in cases where there is a significant gap between the two ends of the injured nerve, bridging strategies are required to repair the defect. The current clinical gold standard is the nerve graft, but this has a number of limitations, including donor site morbidity. An active area of research is focused on developing other techniques to replace these grafts, by creating tubular nerve-guidance conduits from natural and synthetic materials, which are often supplemented with biological cues such as growth factors and regenerative cells. In the present short review, we focus on the use of adipose-tissue-derived stem cells and the possible mechanisms through which they may exert a positive influence on peripheral nerve regeneration, thereby enabling more effective nerve repair.

Place, publisher, year, edition, pages
2014. Vol. 42, 697-701 p.
Keyword [en]
adipose-tissue-derived stem cell, angiogenesis, muscle atrophy, neuroprotection, neurotrophic factor, regeneration
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:umu:diva-90836DOI: 10.1042/BST20140004ISI: 000336826200014OAI: oai:DiVA.org:umu-90836DiVA: diva2:735085
Available from: 2014-07-22 Created: 2014-07-01 Last updated: 2017-12-05Bibliographically approved

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Kolar, Mallappa K.Kingham, Paul J.
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