Detection of IL-17A-producing peripheral blood monocytes in Langerhans cell histiocytosis patients
2014 (English)In: Clinical Immunology, ISSN 1521-6616, E-ISSN 1521-7035, Vol. 153, no 1, 112-122 p.Article in journal (Refereed) Published
Langerhans cell histiocytosis (LCH) is a rare disease of unknown cause with manifestations ranging from isolated granulomatous lesions to life-threatening multi-system organ involvement. This disorder is further characterized by infiltration of immune cells in affected tissues and an association with interleukin (IL)-17A has been reported. Here, we investigated the presence of IL-17A-producing cells among peripheral blood mononuclear cells isolated from LCH patients and observed a high percentage of IL-17A(+) monocytes in peripheral blood of LCH patients compared to controls. The IL-17A(+) monocytes were also positive for the transcription factor retinoic acid orphan receptor (ROR) gamma t and showed increased mRNA levels for both IL-17A and ROR gamma t. Notably, IL-17A was produced by all monocyte subsets and the expression level was positively associated with LCH disease activity. These data support a role for monocytes in the pathogenesis of LCH. Future therapeutic approaches may consider identification of patients who may benefit from IL-17A-targeted interventions.
Place, publisher, year, edition, pages
2014. Vol. 153, no 1, 112-122 p.
Monocytes, Langerhans cell histiocytosis, Interleukin-17A, Retinoic acid orphan receptor gamma t, Retinoic acid orphan receptor C
Immunology in the medical area
IdentifiersURN: urn:nbn:se:umu:diva-91257DOI: 10.1016/j.clim.2014.04.004ISI: 000337935900016OAI: oai:DiVA.org:umu-91257DiVA: diva2:735773