umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Potential upstream regulators of cannabinoid receptor 1 signaling in prostate cancer: A Bayesian network analysis of data from a tissue microarray
Umeå universitet, Samhällsvetenskapliga fakulteten, Handelshögskolan vid Umeå universitet, Statistik.
Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Farmakologi.
Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Farmakologi.
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.
Visa övriga samt affilieringar
2014 (Engelska)Ingår i: The Prostate, ISSN 0270-4137, E-ISSN 1097-0045, Vol. 74, nr 11, s. 1107-1117Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

BACKGROUND The endocannabinoid system regulates cancer cell proliferation, and in prostate cancer a high cannabinoid CB1 receptor expression is associated with a poor prognosis. Down-stream mediators of CB1 receptor signaling in prostate cancer are known, but information on potential upstream regulators is lacking. RESULTS Data from a well-characterized tumor tissue microarray were used for a Bayesian network analysis using the max-min hill-climbing method. In non-malignant tissue samples, a directionality of pEGFR (the phosphorylated form of the epidermal growth factor receptor) CB1 receptors were found regardless as to whether the endocannabinoid metabolizing enzyme fatty acid amide hydrolase (FAAH) was included as a parameter. A similar result was found in the tumor tissue, but only when FAAH was included in the analysis. A second regulatory pathway, from the growth factor receptor ErbB2 FAAH was also identified in the tumor samples. Transfection of AT1 prostate cancer cells with CB1 receptors induced a sensitivity to the growth-inhibiting effects of the CB receptor agonist CP55,940. The sensitivity was not dependent upon the level of receptor expression. Thus a high CB1 receptor expression alone does not drive the cells towards a survival phenotype in the presence of a CB receptor agonist. CONCLUSIONS The data identify two potential regulators of the endocannabinoid system in prostate cancer and allow the construction of a model of a dysregulated endocannabinoid signaling network in this tumor. Further studies should be designed to test the veracity of the predictions of the network analysis in prostate cancer and other solid tumors.

Ort, förlag, år, upplaga, sidor
2014. Vol. 74, nr 11, s. 1107-1117
Nyckelord [en]
prostate cancer, epidermal growth factor, cannabinoid receptor, fatty acid amide hydrolase, directed acyclic graph
Nationell ämneskategori
Cancer och onkologi
Identifikatorer
URN: urn:nbn:se:umu:diva-91251DOI: 10.1002/pros.22827ISI: 000338039700004OAI: oai:DiVA.org:umu-91251DiVA, id: diva2:735780
Tillgänglig från: 2014-07-31 Skapad: 2014-07-28 Senast uppdaterad: 2019-11-25Bibliografiskt granskad

Open Access i DiVA

fulltext(962 kB)292 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 962 kBChecksumma SHA-512
82b77ac435809f52d7b95a555b11fadf3fceb4f9db92ea4954776b2211876bc32a1d7c90f3e150b1d76d45dd98644be0da6cb54198d955c98d2f86fbc7ab5e8a
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltext

Personposter BETA

Häggström, JennyCipriano, MariateresaPlym Forshell, LinusPersson, EmmaHammarsten, PeterFowler, Christopher J.

Sök vidare i DiVA

Av författaren/redaktören
Häggström, JennyCipriano, MariateresaPlym Forshell, LinusPersson, EmmaHammarsten, PeterFowler, Christopher J.
Av organisationen
StatistikFarmakologiOnkologiPatologi
I samma tidskrift
The Prostate
Cancer och onkologi

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 292 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
urn-nbn

Altmetricpoäng

doi
urn-nbn
Totalt: 550 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf