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Vitamin D and multiple sclerosis: where do we go from here?
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
2014 (English)In: Expert Review of Neurotherapeutics, ISSN 1473-7175, E-ISSN 1744-8360, Vol. 14, no 1, 9-18 p.Article, review/survey (Refereed) Published
Abstract [en]

This article briefly introduces the basics of multiple sclerosis' (MS) clinical hallmarks and pathophysiology. Vitamin D is presented, including its metabolism and effects on the immune system. The epidemiological observations linking vitamin D to MS range from a half century old findings of latitude gradients and migrational risk patterns to modern, nested, case-control biobank studies. These observations show an association without doubt although causation has yet to be proven. Vitamin D as a treatment for MS is an emerging concept and both current and anticipated data will be covered. Lastly, we discuss future challenges, ideas on how to move from association to causation, and the prospect of primary prevention of this disabling disease.

Place, publisher, year, edition, pages
Informa , 2014. Vol. 14, no 1, 9-18 p.
Keyword [en]
multiple sclerosis, primary prevention, prospective biobank studies, randomized controlled trials, ultraviolet B (UVB) radiation, vitamin D
National Category
Neurology
Identifiers
URN: urn:nbn:se:umu:diva-91392DOI: 10.1586/14737175.2014.864952ISI: 000338292200003OAI: oai:DiVA.org:umu-91392DiVA: diva2:736118
Available from: 2014-08-05 Created: 2014-08-04 Last updated: 2017-05-11Bibliographically approved

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Salzer, JonatanSundström, Peter

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