Intracerebroventricular infusion of glycine stimulates vasopressin release in conscious sheep.
1993 (English)In: NeuroReport, ISSN 0959-4965, E-ISSN 1473-558X, Vol. 4, no 8, 1052-4 p.Article in journal (Refereed) Published
We have previously observed that elevation of the plasma glycine concentration stimulates vasopressin (AVP) release in man and sheep. In the present study we show that this effect of glycine can be elicited directly via a cerebral site of action in conscious sheep. Intracerebroventricular infusions of 0.05 and 0.15 M glycine solutions increased the plasma AVP concentration by 6 and 50 times, respectively, while no effect on water intake was observed. Hyperhydration did not block the stimulation of AVP release. No behavioural side effects, or changes in blood pressure, were observed in response to the infusions.
Place, publisher, year, edition, pages
1993. Vol. 4, no 8, 1052-4 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:umu:diva-91608PubMedID: 8241463OAI: oai:DiVA.org:umu-91608DiVA: diva2:737391