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Regional changes in cerebral blood flow oxygenation can indicate global changes in cerebral blood flow during coronary artery occlusion in juvenile pigs
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Anaesthesiology.ORCID iD: 0000-0002-5325-2688
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2014 (English)In: Physiological Measurement, ISSN 0967-3334, E-ISSN 1361-6579, Vol. 35, no 7, 1439-1450 p.Article in journal (Refereed) Published
Abstract [en]

Near infrared spectroscopy (NIRS) is a widely employed method for assessment of regional cerebral oxygenation (R(c)StO(2)). RcStO(2) values are expected to vary with changes in the relative amount of oxyhaemoglobin. The present experimental study aimed to assess the response of RcStO(2) to controlled alterations of carotid blood flow (CQ). Landrace pigs were anesthetized followed by surgical preparation. Cyclic variations in cardiac output were accomplished by intermittently occluding the main stem of the left coronary artery. A flow measurement probe for assessing CQ was placed around the left carotid artery. One NIRS probe was placed on the left ipsilateral forehead to assess regional cerebral oximetry. Simultaneous registration of CQ and RcStO(2) was conducted. There was a strong correlation for variation in CQ and RcStO(2) signal values. Based on coherence analysis the fraction of power of the RcStO(2) that was coherent with the CQ signal reached 0.84 - 0.12 (P < 0.05) for frequencies lower than 0.1 Hz. The agreement of the sampleto- sample co-variation, as assessed by the Pearson correlation coefficient, was 0.83 +/- 0.08 (P < 0.05). One explanatory component for variations in cerebral oxygenation verified by NIRS should be attributed to variations in the cerebral blood flow.

Place, publisher, year, edition, pages
IOP Publishing , 2014. Vol. 35, no 7, 1439-1450 p.
Keyword [en]
cerebral oxygenation, near infrared spectroscopy, blood flow, measurement, non-invasive monitoring
National Category
Anesthesiology and Intensive Care
Identifiers
URN: urn:nbn:se:umu:diva-91373DOI: 10.1088/0967-3334/35/7/1439ISI: 000338476000018OAI: oai:DiVA.org:umu-91373DiVA: diva2:737841
Available from: 2014-08-14 Created: 2014-08-04 Last updated: 2017-12-05Bibliographically approved

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Svenmarker, StaffanHäggmark, SörenJohansson, GöranWiklund, UrbanHaney, Michael
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