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Tissue-specific bioconcentration of antidepressants in fish exposed to effluent from a municipal sewage treatment plant
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Umeå University, Faculty of Science and Technology, Department of Chemistry.
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2014 (English)In: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 488, 46-50 p.Article in journal (Refereed) Published
Abstract [en]

Tissue-specific bioconcentration of selected antidepressants was studied in rainbow trout (Oncorhynchus mykiss) exposed to undiluted effluent from a Swedish municipal sewage treatment plant for 13 days. Citalopram, sertraline and venlafaxine were found in the brains and livers of most fish, but not in blood plasma or muscle. Venlafaxine was the only drug found in plasma (3/20 fish). Fluoxetine was not detected in any fish tissue, in accordance with a low concentration in the effluent and a comparably high limit of quantification in tissues. Concentrations of citalopram, sertraline and venlafaxine in fish brain were up to 1/12, 1/8 and 1/26, respectively, of the lowest concentrations found in the brains of mammals treated with therapeutic doses. Thus, given coexposure to several antidepressants and an assumed similar potency in fish, the margin of safety for targetrelated effects in fish residing in effluent-dominated streams is relatively low. Furthermore, the non-detectable levels of these drugs in blood plasma suggest that analyses of concentrations in target tissues (brain) would be more informative in field studies and other studies with environmentally realistic exposure concentrations.

(C) 2014 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 488, 46-50 p.
Keyword [en]
Selective serotonin reuptake inhibitors, Caged fish, Rainbow trout, Liver, Brain, Venlafaxine
National Category
Environmental Sciences Ecology
URN: urn:nbn:se:umu:diva-91745DOI: 10.1016/j.scitotenv.2014.04.052ISI: 000338600800005OAI: diva2:739134
Available from: 2014-08-20 Created: 2014-08-15 Last updated: 2014-08-20Bibliographically approved

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Lindberg, Richard HÖstman, MarcusFick, Jerker
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