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Folic acid supplementation and IVF pregnancy outcome in women with unexplained infertility
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Clinical chemistry.
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2014 (English)In: Reproductive Biomedicine Online, ISSN 1472-6483, E-ISSN 1472-6491, Vol. 28, no 6, 766-772 p.Article in journal (Refereed) Published
Abstract [en]

Folic acid supplements are commonly used by infertile women which leads to a positive folate status. However, the effect of folic acid supplements on pregnancy outcome in women with unexplained infertility has not been well investigated. This study evaluated folic acid supplement use and folate status in women with unexplained infertility in relation to IVF pregnancy outcome. In addition, use of folic acid supplements and folate status were compared between women with unexplained infertility and fertile, nonpregnant control women. Women with unexplained infertility used significantly more folic acid supplements and had higher median total folic acid intake from supplements compared with fertile control women (both P < 0.001). Women with unexplained infertility also had significantly higher median plasma folate and lower median plasma homocysteine concentrations than fertile women (both P < 0.001), but folic acid supplementation or folate status were not related to pregnancy outcome in women with unexplained infertility. In conclusion, folic acid supplementation or good folate status did not have a positive effect on pregnancy outcome following infertility treatment in women with unexplained infertility.

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 28, no 6, 766-772 p.
Keyword [en]
dietary supplement, folate, folic acid, homocysteine, infertility, pregnancy
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
URN: urn:nbn:se:umu:diva-91862DOI: 10.1016/j.rbmo.2014.01.017ISI: 000338862000014OAI: oai:DiVA.org:umu-91862DiVA: diva2:740708
Available from: 2014-08-26 Created: 2014-08-18 Last updated: 2017-12-05Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
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  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf