Cholesterol, CSF 5-HIAA, violence and intent in suicidal men
2010 (English)In: Psychiatry Research, ISSN 0165-1781, E-ISSN 1872-7123, Vol. 178, no 1, 217-219 p.Article in journal (Refereed) Published
Associations between suicide, violent behaviour and both hypocholesterolaemia and low 5-hydroxyindolacetic acid (5-HIAA) in the cerebrospinal fluid (CSF) have been suggested. The relationships between lipids, the serotonergic system, suicidal and aggressive behaviors are complex. We explored relationships between serum cholesterol, CSF 5-HIAA, the planning subscale of suicide intent and violence of attempted suicide method in 13 medication-free male suicide attempters and eight healthy volunteers. Serum high-density lipoprotein cholesterol (HDL-C) levels were significantly lower in suicide attempters than in controls. HDL-C showed a significant positive correlation with the planning subscale of suicide intent in non-violent suicide attempters. A positive association was observed between CSF 5-HIAA and serum cholesterol in suicides. The role of cholesterol may be different in planned non-violent suicide attempts compared with violent suicide attempts.
Place, publisher, year, edition, pages
2010. Vol. 178, no 1, 217-219 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:umu:diva-92382DOI: 10.1016/j.psychres.2008.07.020ISI: 000279489400043PubMedID: 20452040OAI: oai:DiVA.org:umu-92382DiVA: diva2:740823